Switchable on/off drug release from gold nanoparticles-grafted dual light- and temperature-responsive hydrogel for controlled drug delivery
Switchable on/off drug release from gold nanoparticles-grafted dual light- and temperature-responsive hydrogel for controlled drug delivery
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DOI：
10.1016/j.msec.2017.03.038
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发表时间：
2017-07-01
影响因子：
7.9
通讯作者：
Pourghazi, Kamyar
中科院分区：
文献类型：
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作者：
Amoli-Diva, Mitra;Sadighi-Bonabi, Rasoul;Pourghazi, Kamyar
以N，N-亚甲基双丙烯酰胺为交联剂，过硫酸铵为引发剂，采用自由基聚合法制备了金纳米粒子接枝的聚(二甲基丙烯酰胺-共丙烯酰胺)/聚丙烯酸[P(DMA-co-AAm)/PAAc]水凝胶可切换的双光温敏药物载体。用柠檬酸三钠还原水合四氯金酸制备了初始P(DMA-co-AAm)水凝胶和均匀分布的稳定的Au纳米颗粒。然后，将制备的P(DMA-co-AAm)和Au纳米粒子与交联剂和引发剂一起加入到丙烯酸溶液中，在混合物中制备PAAc水凝胶。这提高了网络中的Au纳米粒子的溶胀率和稳定性。此外，还制备了与上述单体组成相同的无规交联型P(DMA-co-AAm-co-AAc)水凝胶，并对其性能进行了比较。然后，研究了所制备的水凝胶在酸性(pH=1.2)和中性(pH=7.4)缓冲溶液中的溶胀性、热敏性和热光开关性能，以模拟胃体和肠体条件。以氧氟沙星类抗生素为模型药物，考察了其在热开关和光开关条件下的载药量和累积释放量(%)。在此基础上，得到了在较高温度下处于“开启”状态，在较低温度下处于“关闭”状态的脉冲式释药载体。(C)2017爱思唯尔B.V.保留所有权利。
A switchable dual light- and temperature-responsive drug carrier using gold nanoparticles (Au NPs)-grafted poly(dimethylacrylamide-co-acrylamide)/poly acrylic acid [P(DMA-co-AAm)/PAAc] hydrogel was prepared by free radical polymerization procedure using N,N-methylenebisacrylamide as cross-linker and ammonium persulfate as initiator. Initial P(DMA-co-AAm) hydrogel and uniformly-distributed stable Au NPs, prepared by reduction of hydrogen tetrachloroaureate (III) hydrate in the presence of trisodium citrate, were synthesized separately. Then, the prepared P(DMA-co-AAm) and Au NPs were added to an acrylic acid solution along with the cross-linker and initiator to prepare PAAc hydrogel within the mixture. This improves the swelling ratio and stabilizes Au NPs in networks. Furthermore, a cross-linked P(DMA-co-AAm-co-AAc) random hydrogel was also prepared with the same monomer compositions as the above hydrogel for comparison of their properties. Then, swelling, thermal sensitivity and thermal and optical switching properties of the prepared hydrogels were investigated in two acidic (pH = 1.2) and neutral (pH = 7.4) buffered solutions to simulate stomach and intestine body conditions. Finally, loading and cumulative release (%) of ofloxacin antibiotic as model drug were considered in both thermal and optical switching conditions. Based on these results, pulsatile release vehicle was obtained which have the "on" state at higher temperatures and the "off" state at lower temperatures. (C) 2017 Elsevier B.V. All rights reserved.