Understanding the complexity of IgE-related phenotypes from childhood to young adulthood: A Mechanisms of the Development of Allergy (MeDALL) Seminar
Understanding the complexity of IgE-related phenotypes from childhood to young adulthood: A Mechanisms of the Development of Allergy (MeDALL) Seminar
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DOI：
10.1016/j.jaci.2012.01.047
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发表时间：
2012-04-01
影响因子：
14.2
通讯作者：
Bousquet, Jean
中科院分区：
文献类型：
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作者：
Anto, Josep M.;Pinart, Mariona;Bousquet, Jean
过敏发生机制 (MeDALL) 是欧盟第七个框架计划项目，旨在产生有关过敏发生机制的新知识。 MeDALL 将定义 IgE 介导的过敏性疾病的精确表型。作为 MeDALL 的一部分，2011 年 1 月 24 日举行了一次科学研讨会，回顾当前有关 IgE 相关表型的知识，并探讨多学科努力如何产生新的综合转化方法。本文提供了会议的摘要。它提出了 IgE 相关表型的挑战以及研究过敏表型的新临床和流行病学方法，包括聚类分析、无标度模型、候选生物标志物和 IgE 微阵列；回顾了严重哮喘的具体病例。然后从个体机制到系统回顾了 IgE 相关表型的新方法，包括表观遗传学、人类体外免疫学、系统生物学和动物模型。最后一章涉及对儿童和青少年中基于人群的 IgE 相关表型的理解，包括成熟方面的年龄效应、生命早期暴露的观察到的影响以及从生命早期到妊娠的焦点转移、基因-环境相互作用、队列效应以及过敏性疾病患者的时间趋势。本综述有助于定义 MeDALL 过敏性疾病的表型。 (J 过敏临床免疫学杂志 2012 年；129:943-54。)
Mechanisms of the Development of Allergy (MeDALL), a Seventh Framework Program European Union project, aims to generate novel knowledge on the mechanisms of initiation of allergy. Precise phenotypes of IgE-mediated allergic diseases will be defined in MeDALL. As part of MeDALL, a scientific seminar was held on January 24, 2011, to review current knowledge on the IgE-related phenotypes and to explore how a multidisciplinary effort could result in a new integrative translational approach. This article provides a summary of the meeting. It develops challenges in IgE-related phenotypes and new clinical and epidemiologic approaches to the investigation of allergic phenotypes, including cluster analysis, scale-free models, candidate biomarkers, and IgE microarrays; the particular case of severe asthma was reviewed. Then novel approaches to the IgE-associated phenotypes are reviewed from the individual mechanisms to the systems, including epigenetics, human in vitro immunology, systems biology, and animal models. The last chapter deals with the understanding of the population-based IgE-associated phenotypes in children and adolescents, including age effect in terms of maturation, observed effects of early-life exposures and shift of focus from early life to pregnancy, gene-environment interactions, cohort effects, and time trends in patients with allergic diseases. This review helps to define phenotypes of allergic diseases in MeDALL. (J Allergy Clin Immunol 2012;129:943-54.)