Arabidopsis mutants sensitive to gamma radiation include the homologue of the human repair gene ERCC1
Arabidopsis mutants sensitive to gamma radiation include the homologue of the human repair gene ERCC1
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DOI：
10.1093/jxb/erg069
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发表时间：
2003-02-01
影响因子：
6.9
通讯作者：
Britt, AB
中科院分区：
文献类型：
--
作者：
Hefner, E;Preuss, SB;Britt, AB
酵母和哺乳动物中对电离辐射敏感的突变体包括各种各样的DNA修复基因。这些DNA修复基因中的大多数参与DNA双链断裂的修复。在这项研究中，正向遗传筛选是用来确定γ敏感突变体的拟南芥。这里使用的γ-小植株筛选还揭示了基于子叶和下胚轴大小的两种一般突变体类别。发现的突变体之一是哺乳动物核苷酸切除修复基因ERCC 1的同源物。
Mutants sensitive to ionizing radiation in yeast and mammals include an assortment of DNA repair genes. The majority of these DNA repair genes are involved in the repair of DNA double-strand breaks. In this study a forward genetic screen is used to identify gamma-sensitive mutants of Arabidopsis thaliana. The gamma-plantlet screen used here also reveals two general mutant classes based on size of cotyledons and hypocotyls. One of the mutants discovered is a homologue of the mammalian nucleotide excision repair gene ERCC1.