Absence of cerebrospinal fluid oligoclonal bands is associated with delayed disability progression in relapsing-remitting MS patients treated with interferon-β
Absence of cerebrospinal fluid oligoclonal bands is associated with delayed disability progression in relapsing-remitting MS patients treated with interferon-β
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DOI：
10.1016/j.jns.2006.01.004
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发表时间：
2006-05-15
影响因子：
4.4
通讯作者：
Maimone, Davide
中科院分区：
文献类型：
--
作者：
Annunziata, Pasquale;Giorgio, Antonio;Maimone, Davide
为了评估脑脊液寡克隆区带(013)在决定复发缓解型多发性硬化症(RRMS)患者接受干扰素-β治疗的临床结果中的作用，我们进行了一项多中心的回顾性观察研究，从意大利北部、中部和南部地区的6个MS中心招募了209名RRMS患者，分别接受干扰素-β-1a肌肉注射、干扰素-β-1a皮下注射治疗。和干扰素-β-1b S.C.209例患者中22例(10.6%)脑脊液中无OB。与有OB的患者相比，无OB的患者在发病时视力障碍的频率(p=0.02)显著高于OB患者(p=0.04)，而感觉损害(p=0.04)明显较少。与OB患者相比，非OB患者在治疗期间达到持续残疾进展的时间更长的统计趋势(p=0.056)。与22例(0%)OB阴性患者相比，OB患者中36例(19%)病情恶化至少1个EDSS积分(p=0.017)。OB阴性患者在治疗期间残疾进展的延迟仅显著依赖于基线磁共振T2加权病变的数量(p=0.012)，而OB阴性患者的T2加权病变数量显著低于OB阳性患者(p=0.04)。在这组MS患者中，没有OB和基线T2加权病变的数量较少是影响RRMS患者对干扰素-β治疗的临床反应的有利预后因素。(C)2006爱思唯尔B.V.保留所有权利。
To assess the role of CSF oligoclonal bands (013) in determining the clinical outcome in patients with relapsing-remitting multiple sclerosis (RRMS) treated with IFN-beta, we carried out a retrospective, multicentre, observational study recruiting 209 RRMS patients from six MS centres from northern, central and southern areas of Italy under treatment with IFN-beta-1a i.m., IFN-beta-1a s.c. and IFN-beta-1b s.c. Twenty-two of 209 patients (10.6%) showed no OB in CSF. The patients without had, at disease onset, significantly higher frequency of visual disturbances (p=0.02) and less sensory involvement (p=0.04) than those with OB. A statistical trend (p=0.056) towards a longer time to reach sustained disability progression during treatment was found in patients without compared to those with OB. Thirty-six of 187 (19%) patients with OB worsened by at least 1 EDSS point compared to none of 22 (0%) OB-negative patients (p=0.017). The delaying of disability progression in OB-negative patients during treatment was significantly dependent only on the number of baseline MRI T2-weighted lesions (p=0.012) that was found to be significantly lower in OB-negative than in OB-positive patients (p=0.04). The absence of OB and low number of baseline T2-weighted lesions in this cohort of MS patients are favourable prognostic factors influencing the clinical response to IFN-beta treatment in RRMS patients. (c) 2006 Elsevier B.V. All rights reserved.