Hand-held optical imager (Gen-2): improved instrumentation and target detectability.
Hand-held optical imager (Gen-2): improved instrumentation and target detectability.
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DOI：
10.1117/1.jbo.17.8.081402
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发表时间：
2012-08
影响因子：
3.5
通讯作者：
Jean Gonzalez;J. Decerce;S. Erickson;Sergio Martinez;A. Nunez;M. Roman;Barbara Traub;C. Flores;Seigbeh M. Roberts;Estrella Hernandez;Wenceslao Aguirre;R. Kiszonas;A. Godavarty
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文献类型：
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作者：
Jean Gonzalez;J. Decerce;S. Erickson;Sergio Martinez;A. Nunez;M. Roman;Barbara Traub;C. Flores;Seigbeh M. Roberts;Estrella Hernandez;Wenceslao Aguirre;R. Kiszonas;A. Godavarty
手持式光学成像仪是由各种研究人员开发的，用于乳腺癌的基于反射的光谱成像。最近，Gen-1手持式光学成像仪被开发，具有执行二维（2-D）光谱以及三维（3-D）断层成像研究的能力。然而，成像仪体积庞大，沿着弯曲组织的表面接触较差（约30%），并且灵敏度有限，无法始终检测目标。在此，已经开发了克服Gen-1成像器的上述限制的Gen-2手持式光学成像器，并且描述了仪器。Gen-2手持式成像仪体积更小、更便携，并且改善了弯曲组织的表面接触（~86%）。此外，叉形探头设计能够同时对两个乳房组织进行双侧反射成像，也能够对单个乳房组织进行透照成像。对组织模型进行了实验研究，以证明使用Gen-2成像仪检测目标的灵敏度提高。与Gen-1成像仪不同，Gen-2成像仪的改进仪器允许独立于目标相对于照明点的位置来检测目标。开发的成像仪具有潜在的未来临床乳腺成像与增强的灵敏度，通过反射和透射成像。
Hand-held optical imagers are developed by various researchers towards reflectance-based spectroscopic imaging of breast cancer. Recently, a Gen-1 handheld optical imager was developed with capabilities to perform two-dimensional (2-D) spectroscopic as well as three-dimensional (3-D) tomographic imaging studies. However, the imager was bulky with poor surface contact (~30%) along curved tissues, and limited sensitivity to detect targets consistently. Herein, a Gen-2 hand-held optical imager that overcame the above limitations of the Gen-1 imager has been developed and the instrumentation described. The Gen-2 hand-held imager is less bulky, portable, and has improved surface contact (~86%) on curved tissues. Additionally, the forked probe head design is capable of simultaneous bilateral reflectance imaging of both breast tissues, and also transillumination imaging of a single breast tissue. Experimental studies were performed on tissue phantoms to demonstrate the improved sensitivity in detecting targets using the Gen-2 imager. The improved instrumentation of the Gen-2 imager allowed detection of targets independent of their location with respect to the illumination points, unlike in Gen-1 imager. The developed imager has potential for future clinical breast imaging with enhanced sensitivity, via both reflectance and transillumination imaging.