SOLUTION STRUCTURE OF KISTRIN, A POTENT PLATELET-AGGREGATION INHIBITOR AND GP-IIB-IIIA ANTAGONIST
SOLUTION STRUCTURE OF KISTRIN, A POTENT PLATELET-AGGREGATION INHIBITOR AND GP-IIB-IIIA ANTAGONIST
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DOI：
10.1126/science.1862345
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发表时间：
1991-07-26
期刊：
影响因子：
56.9
通讯作者：
WAGNER, G
中科院分区：
文献类型：
--
作者：
ADLER, M;LAZARUS, RA;WAGNER, G
kistrin是糖蛋白IIb-IIIa（GP IIb-IIIa）拮抗剂和血小板聚集的有效蛋白质抑制剂的同源家族的成员，其结构已通过二维核磁共振（NMR）光谱测定。68个残基的蛋白质由一系列紧密堆积的环组成，通过六个二硫键连接在一起，几乎没有规则的二级结构。Kistrin具有Arg-Gly-Asp（RGD）粘附位点识别序列，其对于结合GP IIb-IIIa是重要的，其位于横跨蛋白质表面的长环的顶点。
The structure of kistrin, which is a member of a homologous family of glycoprotein IIb-IIIa (GP IIb-IIIa) antagonists and potent protein inhibitors of platelet aggregation, has been determined by two-dimensional nuclear magnetic resonance (NMR) spectroscopy. The 68-residue protein consists of a series of tightly packed loops held together by six disulfide bonds and has almost no regular secondary structure. Kistrin has an Arg-Gly-Asp (RGD) adhesion site recognition sequence important for binding to GP IIb-IIIa that is located at the apex of a long loop across the surface of the protein.