Nerve growth factor injected systemically improves the recovery of the inferior alveolar nerve in a rabbit model of mandibular distraction osteogenesis
Nerve growth factor injected systemically improves the recovery of the inferior alveolar nerve in a rabbit model of mandibular distraction osteogenesis
复制标题
全身注射神经生长因子改善兔下颌骨牵张成骨模型下牙槽神经的恢复
DOI：
10.1016/j.bjoms.2011.07.002
复制
发表时间：
2011-10-01
影响因子：
1.8
通讯作者：
Ma, Qin
中科院分区：
文献类型：
--
作者：
Du, Zhao-jie;Wang, Lei;Ma, Qin
我们的目的是找出是否神经生长因子（NGF）全身注射可以促进下牙槽神经在兔下颌骨牵张成骨模型的恢复。我们使用48只新西兰白色兔，以0.5 mm/12 h的速度进行双侧牵张成骨，持续10天。术后立即肌内注射NGF或氯化钠0.6 μ g/天，持续20天。在牵引结束时和巩固时间后的1，2，和4周，下牙槽神经进行了组织学和组织形态计量学评价。在组织学上，在2周和4周时，与对照组相比，NGF中存在较少的髓鞘碎片和更多的再生轴突。在第2周和第4周，NGF组的有髓轴突密度显著高于对照组（p < 0.05）。全身给予NGF可促进兔下颌骨牵张成骨术后下牙槽神经的恢复，是治疗下颌骨牵张成骨术后神经系统并发症的有效方法。(C)2011年英国口腔颌面外科医师协会。由爱思唯尔有限公司出版。保留所有权利。
Our aim was to find out if nerve growth factor (NGF) injected systemically could improve the recovery of the inferior alveolar nerve in a rabbit model of mandibular distraction osteogenesis. We used 48 New Zealand white rabbits that were treated with bilateral distraction osteogenesis at a rate of 0.5 mm/12h for 10 days. Immediately postoperatively, NGF or sodium chloride 0.6 mu g/day was injected intramuscularly for 20 days. At the end of distraction and after consolidation times of 1, 2, and 4 weeks, the inferior alveolar nerves were evaluated histologically and histomorphometrically. Histologically, at 2 and 4 weeks there was less myelin debris, and more regenerating axons were present, in the NGF than the control groups. The density of myelinated axons was significantly greater in groups with NGF than controls at 2 and 4 weeks (p < 0.05). NGF given systemically can accelerate the recovery of the inferior alveolar nerve in rabbits after mandibular distraction osteogenesis, and is a promising treatment option for neurological complications of mandibular distraction osteogenesis. (C) 2011 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.