New insights into the roles of ATM and DNA-PKcs in the cellular response to oxidative stress
New insights into the roles of ATM and DNA-PKcs in the cellular response to oxidative stress
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DOI：
10.1016/j.canlet.2011.12.004
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发表时间：
2012-12-31
期刊：
影响因子：
9.7
通讯作者：
Asaithamby, Aroumougame
中科院分区：
文献类型：
--
作者：
Chen, Benjamin P. C.;Li, Mengxia;Asaithamby, Aroumougame
活性氧(ROS)是由多种内源和外源引起的。处于病态的高水平。ROS会对包括DNA在内的生物分子造成损害。DNA的损伤可能在衰老和癌变的发病机制中起着关键作用。广泛的研究已经详细地建立了细胞对氧化应激的反应机制。目前关注的焦点是确定关键的DNA损伤反应蛋白激酶突变的毛细血管扩张性共济失调(ATM)、DNA依赖的蛋白激酶催化亚单位(DNA-PKcs)以及ATM和Rad3相关的(AIR)在氧化应激反应中的分子作用。在这篇综述中，我们将提供有关这些相关的DNA损伤反应激酶参与DNA氧化损伤修复和信号反应的最新证据。对ATM、DNA-PKcs和ATR参与氧化应激反应的了解日益加深，这将为ROS相关疾病的治疗提供新的可能性。(C)2011爱思唯尔爱尔兰有限公司。保留所有权利。
Reactive oxygen species (ROS) are induced by a variety of endogenous and exogenous sources. At pathologically high levels. ROS cause damage to biological molecules, including DNA. The damage sustained by DNA likely plays a key role in the pathogenesis of aging and carcinogenesis. Extensive research has established in detail the mechanism of cellular response to oxidative stress. Attention is now focused on identifying the molecular contributions of the key DNA damage response kinases Ataxia telangiectasia mutated (ATM), DNA-dependent protein kinase catalytic subunit (DNA-PKcs), and ATM- and Rad3-related (AIR) in the oxidative stress response. In this review, we will provide an update of the current evidence regarding the involvement of these related DNA damage response kinases in oxidative DNA lesion repair and signaling responses. The growing understanding of the involvement of ATM, DNA-PKcs, and ATR in the oxidative stress response will offer new possibilities for the treatment of ROS-related diseases. (c) 2011 Elsevier Ireland Ltd. All rights reserved.