The Diurnal Secretory Characteristics of Individual Meibomian Glands
The Diurnal Secretory Characteristics of Individual Meibomian Glands
复制标题
DOI：
10.1097/ico.0b013e3181ac9fd0
复制
发表时间：
2010-01-01
期刊：
影响因子：
2.8
通讯作者：
Korb, Donald R.
中科院分区：
文献类型：
--
作者：
Blackie, Caroline A.;Korb, Donald R.
目的：研究个体眉板腺(MGs)的昼夜分泌特征。方法：选择眼睑外观健康、无干眼症状的受试者10例，平均年龄23.8±1.8岁。在右、左下眼睑的3个位置进行标记，以在下眼睑的每1/3(颞部、中央部和鼻部)处定位5个连续的MG。每只眼睛每眼诊断性地表达15毫克，每3小时在左右下眼皮上诊断表达10秒，在9小时内连续测量4次。结果：在所有测试的毫克中，34%的人在所有测量中产生液体分泌。69%的鼻部MG在所有测量中都能产生液体分泌，相比之下，中央MG的比例为31%，颞部MG的比例仅为22%。在所有测量中，鼻部分泌液体油的MG的平均数量显著高于中央和颞部(p<；0.001)。结论：(1)单个MG能够在一天的工作过程中(接近9小时)按需分泌液体油；(2)与颞部相比，鼻部MG在一天中最有可能根据需要分泌液体油，中枢性MG的分泌程度较小；(3)单个MG的分泌特征不随其在下眼皮中的位置而变化。
Purpose: To investigate the diurnal secretory characteristics of individual meibomian glands (MGs).Methods: Ten subjects (4 females and 6 males) with healthy eyelid appearance and without dry eye symptoms were recruited (mean age = 23.8 +/- 1.8 years). Both right and left lower eyelids were marked in 3 places to locate 5 consecutive MGs in each third (temporal, central, and nasal) of the lower eyelid. A total of 15 MGs per eye were diagnostically expressed for 10 seconds on both right and left lower eyelids every 3 hours for 4 consecutive measurements over a 9-hour period.Results: Thirty-four percent of all tested MGs yielded liquid secretion at all measurements. Sixty-nine percent of the tested nasal MGs yielded liquid secretion at all measurements in contrast to 31% of the central MGs and only 22% of the temporal MGs. The mean numbers of MGs secreting liquid oil were significantly higher in the nasal section relative to the central and temporal sections at all measurements (p < 0.001, all measurements).Conclusions: (1) A single MG is capable of secreting oil on demand over the course of a working day (similar to 9 hours); (2) nasal MGs were the most likely to secrete upon demand over the course of day compared with the temporal and to a lesser degree the central MGs; and (3) secretory characteristics of individual MGs examined as a function of their location in the lower eyelid does not change diurnally.