Novel betaines from a micronesian sponge Dysidea herbacea.
Novel betaines from a micronesian sponge Dysidea herbacea.
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DOI：
10.1021/jo0355045
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发表时间：
2004-01
期刊：
影响因子：
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通讯作者：
R. Sakai;Katsuji Suzuki;K. Shimamoto;H. Kamiya
中科院分区：
文献类型：
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作者：
R. Sakai;Katsuji Suzuki;K. Shimamoto;H. Kamiya
从采集于密克罗尼西亚雅普州的海绵Dysideaherbacea的水提物中分离得到三个新的甜菜碱，即dysibetaine PP（1）、dysibetaine CPa（2）和dysibetaine CPb（3）。化合物1的结构经光谱和化学降解确定为一种新的二肽甜菜碱，化合物2和3的结构经化学降解确定为一种新的环丙烷甜菜碱。在放射性配体结合试验中，化合物2和3分别对N-甲基-D-天冬氨酸型和红藻氨酸型谷氨酸受体表现出弱亲和力。
Three new betaines, dysibetaine PP (1), dysibetaine CPa (2), and dysibetaine CPb (3), were isolated from an aqueous extract of the marine sponge Dysidea herbacea collected in Yap state, Micronesia. The structure of 1 was determined by spectral methods as well as chemical degradation to be a novel dipeptide betaine, and those for 2 and 3 were determined to be unprecedented cyclopropane betaines. Compounds 2 and 3 showed weak affinity toward the N-methyl-D-aspartic acid-type and the kainic acid-type glutamate receptors, respectively, in a radioligand binding assay.