STIMULATION OF DNA SYNTHESIS IN ADULT RAT HEPATOCYTES IN PRIMARY CULTURE BY SERA FROM PATIENTS WITH FULMINANT HEPATIC FAILURE
STIMULATION OF DNA SYNTHESIS IN ADULT RAT HEPATOCYTES IN PRIMARY CULTURE BY SERA FROM PATIENTS WITH FULMINANT HEPATIC FAILURE
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暴发性肝衰竭患者血清对原代培养成年大鼠肝细胞 DNA 合成的刺激
DOI：
10.2220/biomedres.6.231
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发表时间：
1985
影响因子：
1.2
通讯作者：
S. Hashimoto
中科院分区：
文献类型：
--
作者：
H. Nakayama;H. Tsubouchi;E. Gohda;M. Koura;J. Nagahama;H. Yoshida;Y. Daikuhara;S. Hashimoto
用原代培养的成年大鼠肝细胞观察了9例暴发性肝衰竭患者血清对肝细胞生长的影响。所有9种血清刺激肝细胞中的DNA合成比正常人血清更有效，正常人血清仅具有轻微的促生长活性。其中4份血清对DNA合成的刺激活性是正常人血清的10倍以上。具有最高活性的血清具有剂量依赖性作用，并且其在10%浓度下的作用大于最佳浓度的胰岛素和表皮生长因子的组合。放射自显影和形态学数据显示，在该血清存在下复制和数量增加的细胞是实质肝细胞。
The effect of sera from nine patients with fulminant hepatic failure on liver cell growth was investigated by use ofadult rat liver cells in primary culture. All nine sera stimulated DNA synthesis in hepatocytes more effectively than normal human serum, which had only slight growth-promoting activity. Moreover four ofthe sera showed marked stimulatory activity on DNA synthesis of more than 10 times that of normal human serum. The serum with the highest activity had a dose-dependent effect, and its effect at 10% concentration was greater than that of a combination of the optimal concentrations of insulin and epidermal growth factor. Autoradiographic and morphological data showed that cells that replicated and increased in number in the presence of this serum were parenchymal hepatocytes.
两种血清因子控制肝细胞复制。
影响因子：
11.2
作者：
Michalopoulos,G;Houck,KA;Dolan,ML;Leutteke,NC
通讯作者：
Leutteke,NC
前列腺素对 S 期 DNA 合成的非 cAMP 依赖性抑制的证据。
DOI：
--
发表时间：
1983
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Wiley,MH;Feingold,KR;Grunfeld,C;Quesney-Huneeus,V;Wu,JM
通讯作者：
Wu,JM
原代培养中大鼠肝细胞的肝再生研究。
影响因子：
11.2
作者：
Michalopoulos,G;Cianciulli,HD;Novotny,AR;Kligerman,AD;Strom,SC;Jirtle,RL
通讯作者：
Jirtle,RL