Neuroticism: A vulnerability marker for depression evidence from a family study
Neuroticism: A vulnerability marker for depression evidence from a family study
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DOI：
10.1016/0165-0327(95)00062-3
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发表时间：
1995-12-13
影响因子：
6.6
通讯作者：
Murray, R
中科院分区：
文献类型：
--
作者：
Duggan, C;Sham, P;Murray, R
简介：我们利用家庭研究的数据，研究了艾森克人格量表 (EPI) 中的抑郁症与人格特质之间的关系。方法：将 89 名 RDC 重性抑郁 (MD) 先证者的一级亲属按其终生 RDC 诊断细分为：(1) 已从 MD 康复的亲属 (n = 34)； (2) 从未患病的亲属 (n = 45)。使用多级线性模型比较这两组的神经质（N）和外向性（E）分数，考虑到潜在的混杂因素。还检查了第 1 组中 MD 发病年龄和复发与 N 评分之间的关系。 结果：（1）N 评分升高与既往重性抑郁病史相关。 (2) E 分数不存在这种关系。 (3)当前抑郁症状也与N评分增加相关，但这并不能解释既往重度抑郁与N评分之间的关系，(4)康复MD亲属中重度抑郁的复发与N评分增加显着相关。结论：这些数据表明，升高的N可能是重度抑郁症的脆弱性标志。
Introduction: We investigated the relationship between depressive illness and personality traits from the Eysenck Personality Inventory (EPI) using data from a family study.Methods: The first-degree relatives of a series of 89 probands with RDC major depression (MD) were subdivided by their lifetime RDC diagnosis into: (1) relatives recovered from MD (n = 34); (2) never-ill relatives (n = 45). The neuroticism (N) and extraversion (E) scores of these two groups were compared using a multilevel linear model, allowing for potential confounders. The relationship between age of onset and recurrence of MD and N scores in group 1 was also examined.Results: (1) Raised N scores were associated with a past history of major depression. (2) There was no such relationship for E scores. (3) Current depressive symptoms were also associated with an increased N score but this did not explain the relationship between previous major depression and N scores, (4) Recurrent episodes of major depression in the recovered MD relatives;were significantly associated with increased N scores.Conclusion: These data suggest that raised N may be a vulnerability marker for major depression.