Is Crohn's disease due to defective immunity?
Is Crohn's disease due to defective immunity?
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DOI：
10.1136/gut.2006.095588
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发表时间：
2007-01-01
期刊：
影响因子：
24.5
通讯作者：
Korzenik, J. R.
中科院分区：
文献类型：
--
作者：
Korzenik, J. R.
对克罗恩病的病理生理学的理解目前正在重新评估。这种疾病作为一种原发性T细胞疾病的概念正在受到质疑，新的重点是先天免疫在启动早期事件和维持炎症状态中的作用。克罗恩病被认为是先天免疫受损的结果，包括粘膜屏障和细胞成分，包括嗜中性粒细胞和巨噬细胞。遗传学、先天免疫功能研究和克罗恩病患者治疗试验的最新进展支持了这一不断发展的假说。
The understanding of the pathophysiology of Crohn’s disease is currently undergoing a reassessment. The concept of this disease as a primary T cell disorder is being questioned, with a new emphasis on the role of innate immunity in initiating early events and in perpetuating the inflammatory state. Crohn’s disease has been proposed instead to result from impaired innate immunity, encompassing the mucosal barrier and cellular elements including neutrophils and macrophages. Recent advances in genetics, functional studies on innate immunity and therapeutic trials on patients with Crohn’s disease have lent support to this evolving hypothesis.