Innate Immune Activity in Glomerular Podocytes.
Innate Immune Activity in Glomerular Podocytes.
复制标题
肾小球足细胞的先天免疫活性
DOI：
10.3389/fimmu.2017.00122
复制
发表时间：
2017
影响因子：
7.3
通讯作者：
Shi S
中科院分区：
文献类型：
--
作者：
Xia H;Bao W;Shi S
Glomerular podocytes are specialized in structure and play an essential role in glomerular filtration. In addition, podocyte stress can initiate glomerular damage by inducing the injury of other glomerular cell types. Studies have shown that podocytes possess the property of immune cells and may be involved in adaptive immunity. Emerging studies have also shown that podocytes possess signaling pathways of innate immune responses and that innate immune responses often result in podocyte injury. More recently, mitochondrial-derived damage-associated molecular patterns (mtDAMPs) have been shown to play a critical role in a variety of pathological processes in cells. In the present mini-review, we summarize the recent advances in the studies of innate immunity and its pathogenic role in podocytes, particularly, from the perspective of mtDAMPs.
