Satellite cell depletion in degenerative skeletal muscle
Satellite cell depletion in degenerative skeletal muscle
复制标题
DOI：
10.1023/a:1026127307457
复制
发表时间：
2003-12-01
期刊：
影响因子：
7.2
通讯作者：
Kuzon, WM
中科院分区：
文献类型：
--
作者：
Jejurikar, SS;Kuzon, WM
成人骨骼肌在受伤后具有惊人的自我修复和再生能力。如果没有卫星细胞，这是不可能的，卫星细胞是存在于肌纤维边缘的细胞亚群。在大多数情况下，卫星细胞是静止的，但它们在受到创伤时被激活，使它们能够引导骨骼肌再生。在骨骼肌退行性状态下，包括运动神经失支配、高龄、退行性或固定性萎缩以及杜氏肌营养不良，卫星细胞数量和增殖潜力显著下降，导致骨骼肌再生能力和收缩能力下降。这篇综述将强调卫星细胞在几种涉及骨骼肌的退行性疾病中的命运，并将试图衡量细胞凋亡、衰老、增殖潜力受损和宿主因素对卫星细胞功能障碍的相对贡献。
Adult skeletal muscle has the striking ability to repair and regenerate itself after injury. This would not be possible without satellite cells, a subpopulation of cells existing at the margin of the myofiber. Under most conditions, satellite cells are quiescent, but they are activated in response to trauma, enabling them to guide skeletal muscle regeneration. In degenerative skeletal muscle states, including motor nerve denervation, advanced age, atrophy secondary to deconditioning or immobilization, and Duchenne muscular dystrophy, satellite cell numbers and proliferative potential significantly decrease, contributing to a diminution of skeletal muscle's regenerative capacity and contractility. This review will highlight the fate of satellite cells in several degenerative conditions involving skeletal muscle, and will attempt to gauge the relative contributions of apoptosis, senescence, impaired proliferative potential, and host factors to satellite cell dysfunction.