Cytolethal distending toxin: a bacterial bullet targeted to nucleus.
Cytolethal distending toxin: a bacterial bullet targeted to nucleus.
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细胞致死膨胀毒素：一种针对细胞核的细菌子弹。
DOI：
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发表时间：
2004
期刊：
影响因子：
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通讯作者：
M. Sugai
中科院分区：
文献类型：
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作者：
M. Ohara;É. Oswald;M. Sugai
细胞致死膨胀毒素（Cdt）是一种新发现的劫持真核细胞控制系统的细菌蛋白毒素。Cdts是由几种引起慢性传染病的致病菌产生的。它们由三个亚基CdtA， CdtB和CdtC组成，它们一起形成三元配合物。CdtB是活性成分，CdtA和CdtC参与将CdtB运送到细胞中。Cdt控制宿主细胞的复杂策略是cdtb介导的宿主细胞染色体的有限DNA损伤，它触发细胞周期检查点的反应并导致细胞中的G2阻滞。Cdt还可诱导淋巴细胞凋亡，这可能与产生细菌的慢性感染的发生或持续有关。对这种毒素的研究有望为我们提供细菌与宿主细胞相互作用的新策略的信息。
Cytolethal distending toxin (Cdt) is a newly added member of bacterial protein toxins that hijack the control system of eukaryotic cells. Cdts are produced by several pathogenic bacteria causing chronic infectious diseases. They are composed of three subunits, CdtA, CdtB and CdtC, which together form a ternary complex. CdtB is the active component, and CdtA and CdtC are involved in delivering the CdtB into the cells. The sophisticated strategy of Cdt to control host cells is CdtB-mediated limited DNA damage of the host cell chromosome, which triggers the response of the cell cycle checkpoint and results in G2 arrest in the cells. Cdt also induces apoptotic cell death of lymphocytes, which may be relevant to onset or persistence of chronic infection by the producing bacteria. The study of this toxin is expected to provide us information on a novel strategy by which bacteria interact with host cells.