Effect of Preservatives on Systemic Delivery of Insulin by Ocular Instillation in Rabbits
Effect of Preservatives on Systemic Delivery of Insulin by Ocular Instillation in Rabbits
复制标题
防腐剂对家兔眼部滴注胰岛素全身输送的影响
DOI：
10.1111/j.2042-7158.1994.tb05705.x
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发表时间：
1994
影响因子：
3.3
通讯作者：
J. Nakamura
中科院分区：
文献类型：
--
作者：
H. Sasaki;Choyu Tei;K. Yamamura;K. Nishida;J. Nakamura
Abstract— The effects of absorption promoters and ophthalmic preservatives on the systemic absorption of insulin through the ocular route were investigated in albino rabbits. Insulin absorption was evaluated by its hypoglycaemic response. Although ocular instillation of insulin alone did not decrease the serum glucose concentration, instillation of insulin with absorption promoters such as EDTA and saponin decreased it. The promoting effect depended on the concentration of the absorption promoters. Of ophthalmic preservatives investigated (benzalkonium chloride, paraben, 2‐phenylethanol, benzyl alcohol and sorbic acid), benzal‐konium, chloride and paraben showed promoting effects. The promoting effect for benzalkonium chloride was reversible and dependent on concentration of both benzalkonium chloride and insulin in the formulation.
体内测量的角膜对眼科防腐剂的有氧反应。
影响因子：
4.4
作者：
Burton,GD;Hill,RM
通讯作者：
Hill,RM
影响因子：
4.4
作者：
Burstein,NL
通讯作者：
Burstein,NL
通过眼部途径全身递送多肽药物。
DOI：
10.1146/annurev.pa.31.040191.002325
发表时间：
1991
影响因子：
12.5
作者：
Chiou,GC
通讯作者：
Chiou,GC