Analysing Gene Networks with PDP Systems. Arabidopsis thaliana, a Case Study
Analysing Gene Networks with PDP Systems. Arabidopsis thaliana, a Case Study
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发表时间：
2013
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通讯作者：
L. V. Cabrera;Manuel García Quismondo;M. D. Jiménez;Yansen Su;Hui Yu;L. Pan
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作者：
L. V. Cabrera;Manuel García Quismondo;M. D. Jiménez;Yansen Su;Hui Yu;L. Pan
基因调控网络（GRNs）是生物学家了解生物体中基因间相互作用的有用工具。最近推出了一种称为逻辑网络（LN）的特殊类型的GRN。这些网络认为一个或多个基因的状态可以影响另一个基因。在以前的工作中，我们提出了一个膜计算模型，通过借鉴改进的LAPP算法来模拟LN的动力学。在本文中，我们为我们的LN模型提供了一个案例研究，该网络调节长期研究的植物拟南芥的昼夜节律。我们概述了所采用的软件工具，并提出了一种方法来分析我们的膜计算模型的LN。最后，对全文进行了总结和展望.
Gene Regulatory Networks (GRNs) are a useful tool for biologists to understand the interactions among genes in living organisms. A special kind of GRNs known as Logic Networks (LNs) has been recently introduced. These networks consider that the state of one or more genes can influence another one. In a previous work, we proposed a Membrane Computing model which simulates the dynamics of LNs by drawing on the improved LAPP algorithm. In this paper we provide a case study for our LN model on a network which regulates the circadian rhythms of long–term studied plant Arabidopsis thaliana. We outline the software tools employed and propose a methodology for analysing LNs on our Membrane Computing model. At the end of the paper, some conclusions and future work are included.