Greater response variability in adolescents is associated with increased white matter development.
Greater response variability in adolescents is associated with increased white matter development.
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DOI：
10.1093/scan/nsw132
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发表时间：
2017-03-01
影响因子：
4.2
通讯作者：
Galván A
中科院分区：
文献类型：
--
作者：
Goldenberg D;Telzer EH;Lieberman MD;Fuligni AJ;Galván A
青春期是学习、探索和不断适应波动环境的时期。青春期的反应变异是一种重要的、未被充分研究的、适合发育的行为。本研究的目的是确定 48 名青少年（14-16 岁）样本中动态风险决策任务的表现与白质微观结构之间的关联。对任务反应变化最大的个人获得了最广泛的经验以及风险选择的潜在结果。与行为更加一致的同龄人相比，反应变异性较大的青少年通过自我报告将现实世界中冒险行为的例子评为风险较小。基于束的空间统计 (TBSS) 用于检查分数各向异性 (FA) 和平均扩散率 (MD)。长程晚熟花束中较高的 FA 与较高的反应变异性相关。较高的 FA 和较低的 MD 与现实世界风险行为的较低风险评级相关。结果表明，青少年的神经成熟支持反应变异性和对现实世界风险的较低感知风险态度。
Adolescence is a period of learning, exploration, and continuous adaptation to fluctuating environments. Response variability during adolescence is an important, understudied, and developmentally appropriate behavior. The purpose of this study was to identify the association between performance on a dynamic risky decision making task and white matter microstructure in a sample of 48 adolescents (14–16 years). Individuals with the greatest response variability on the task obtained the widest range of experience with potential outcomes to risky choice. When compared with their more behaviorally consistent peers, adolescents with greater response variability rated real-world examples of risk taking behaviors as less risky via self-report. Tract-Based Spatial Statistics (TBSS) were used to examine fractional anisotropy (FA) and mean diffusivity (MD). Greater FA in long-range, late-maturing tracts was associated with higher response variability. Greater FA and lower MD were associated with lower riskiness ratings of real-world risky behaviors. Results suggest that response variability and lower perceived risk attitudes of real-world risk are supported by neural maturation in adolescents.