Lytic regulated cell death in aquaculture fish
Lytic regulated cell death in aquaculture fish
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DOI：
10.1111/raq.12533
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发表时间：
2021-02
影响因子：
10.4
通讯作者：
X. Xia;Bin He;Xiulin Zhang;Zhe Cheng;Mingcheng Liu;Xiaobing Wei;Jinqing Jiang;Jianhe Hu
中科院分区：
文献类型：
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作者：
X. Xia;Bin He;Xiulin Zhang;Zhe Cheng;Mingcheng Liu;Xiaobing Wei;Jinqing Jiang;Jianhe Hu
细胞死亡是多细胞动物的一种重要生理病理现象，广泛存在于机体的各个系统。近年来，研究人员对哺乳动物细胞坏死和凋亡的机制有了更深入的了解。此外，还发现了许多新的裂解性调节性细胞死亡（RCD）形式，如细胞凋亡（pyroptosis）、坏死性凋亡（necroptosis）和铁凋亡（ferroptosis），从而加深了人们对程序性细胞死亡（PCD）的分子机制、相关信号通路及其与疾病关系的认识。然而，我们对鱼类溶解性RCD的了解有限。近年来，在鱼类裂解性RCD的诱导条件、相关基因的表达及调控方面取得了一些进展。此外，关于裂解性RCD在组织发育、抵抗病原微生物、炎性疾病和神经系统疾病中的作用的研究也取得了进展。了解鱼类中的溶解性RCD，将使其发生的调控，通过人为干预，抑制疾病的过程，改善鱼类的健康，并在这些基础理论研究的基础上探索可能的对策。
Cell death is an important physiological and pathological phenomenon in multicellular animals and occurs widely in various body’s systems. In recent years, researchers have gained a deeper understanding of the mechanisms of necrosis and apoptosis in mammals. In addition, many new forms of lytic regulated cell death (RCD), such as pyroptosis, necroptosis and ferroptosis, have been discovered, thus enhancing our understanding of the molecular mechanisms of programmed cell death (PCD) and the associated signalling pathways as well as their relationship with diseases. However, our understanding of lytic RCD in fish is limited. Recently, some progress has been made regarding the induction conditions, expression of related genes and regulation of lytic RCD in fish. Furthermore, research on the roles of lytic RCD in tissue development, against pathogenic microorganism, inflammatory disease and neurological disease, has also been advanced. Understanding lytic RCD in fish will enable the regulation of its occurrence through human intervention to inhibit disease processes, improve fish health and explore possible countermeasures based on these basic theoretical studies.