Balancing Innate Immunity and Inflammatory State via Modulation of Neutrophil Function: A Novel Strategy to Fight Sepsis.
Balancing Innate Immunity and Inflammatory State via Modulation of Neutrophil Function: A Novel Strategy to Fight Sepsis.
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通过调节中性粒细胞功能平衡先天免疫和炎症状态：对抗脓毒症的新策略。
DOI：
10.1155/2015/187048
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发表时间：
2015
影响因子：
4.1
通讯作者：
Dahmen U
中科院分区：
文献类型：
--
作者：
Fang H;Jiang W;Cheng J;Lu Y;Liu A;Kan L;Dahmen U
脓毒症和SIRS（全身炎症反应综合征）属于以感染和/或全身炎症状态为特征的严重疾病复合体。越来越多的证据表明，中性粒细胞积极参与败血症，并负责细胞因子的释放和病原体的吞噬。中性粒细胞水平主要由细胞因子和药物G-CSF调节，广泛用于中性粒细胞减少的脓毒症患者。本文将简要总结中性粒细胞在脓毒症中的作用以及G-CSF的治疗效果。我们进一步表明，针对中性粒细胞功能来调节先天免疫和炎症损伤之间的平衡可能是脓毒症的一种有价值的治疗策略。
Sepsis and SIRS (systemic inflammatory response syndrome) belong to a severe disease complex characterized by infection and/or a whole-body inflammatory state. There is a growing body of evidence that neutrophils are actively involved in sepsis and are responsible for both release of cytokines and phagocytosis of pathogens. The neutrophil level is mainly regulated by G-CSF, a cytokine and drug, which is widely used in the septic patient with neutropenia. This review will briefly summarize the role of neutrophils and the therapeutic effect of G-CSF in sepsis. We further suggest that targeting neutrophil function to modulate the balance between innate immunity and inflammatory injury could be a worthwhile therapeutic strategy for sepsis.