Parametric Solid Models of the At-Term Uterus From Magnetic Resonance Images.
Parametric Solid Models of the At-Term Uterus From Magnetic Resonance Images.
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来自磁共振图像的足月子宫参数化实体模型。
DOI：
10.1115/1.4065109
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发表时间：
2024
期刊：
影响因子：
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通讯作者：
Myers,KristinM
中科院分区：
文献类型：
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作者：
Louwagie,ErinM;Rajasekharan,Divya;Feder,Arielle;Fang,Shuyang;Nhan-Chang,Chia-Ling;Mourad,Mirella;Myers,KristinM
人们对分娩机制知之甚少，尽管分娩过程中的许多损伤都是机械性的，比如胎儿和母体组织的损伤。已经提出了几种分娩的生物力学模拟模型来研究分娩，但许多模型不包括子宫。此外，大多数实体模型依赖于从临床图像中分割解剖结构来生成患者几何图形，这可能会很耗时。这项工作提出了两种新的参数实体建模方法，用于生成特定于患者的足月子宫三维几何图形。这项工作建立在已建立的矢状子宫形状建模方法基础上，改善了子宫冠状形状，特别是在胎头与子宫壁下部连接的地方。从五个足月患者的磁共振成像(MRI)设备中建立了子宫和宫颈的实体模型。使用MRI分段模型的解剖学测量，创建了两个参数模型-一个使用平均冠状子宫形状，另一个使用冠状子宫的多个轴向测量。通过有限元分析，将这两种新的参数方法与MRI分段高保真方法和先前发表的椭圆低保真方法进行了比较。使用两种新的参数方法发现足月子宫形态有了明显的改善，并且所有建模方法在主要拉格朗日应变方向上都观察到了一致。这些方法提供了一种有效和高效的方法来生成特定于患者的母体子宫解剖的三维实体模型，为计算分娩生物力学的未来研究提供了可能性。
Birthing mechanics are poorly understood, though many injuries during childbirth are mechanical, like fetal and maternal tissue damage. Several biomechanical simulation models of parturition have been proposed to investigate birth, but many do not include the uterus. Additionally, most solid models rely on segmenting anatomical structures from clinical images to generate patient geometry, which can be time-consuming. This work presents two new parametric solid modeling methods for generating patient-specific, at-term uterine three-dimensional geometry. Building from an established method of modeling the sagittal uterine shape, this work improves the uterine coronal shape, especially where the fetal head joins the lower uterine wall. Solid models of the uterus and cervix were built from five at-term patients' magnetic resonance imaging (MRI) sets. Using anatomy measurements from MRI-segmented models, two parametric models were created—one that employs an averaged coronal uterine shape and one with multiple axial measurements of the coronal uterus. Through finite element analysis, the two new parametric methods were compared to the MRI-segmented high-fidelity method and a previously published elliptical low-fidelity method. A clear improvement in the at-term uterine shape was found using the two new parametric methods, and agreement in principal Lagrange strain directions was observed across all modeling methods. These methods provide an effective and efficient way to generate three-dimensional solid models of patient-specific maternal uterine anatomy, advancing possibilities for future research in computational birthing biomechanics.