Phylogenomic analysis of polyketide synthase-encoding genes in Trichoderma
Phylogenomic analysis of polyketide synthase-encoding genes in Trichoderma
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DOI：
10.1099/mic.0.053462-0
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发表时间：
2012-01-01
期刊：
影响因子：
2.8
通讯作者：
Kubicek, Christian P.
中科院分区：
文献类型：
--
作者：
Baker, Scott E.;Perrone, Giancarlo;Kubicek, Christian P.
经济上重要的子囊菌属木霉的成员普遍分布在世界各地。木霉菌的寄生生活方式和植物防御诱导相互作用。使其成为理想的生物防治剂。在产生次级代谢物的木霉酶中，其中一些可能在生物防治过程中发挥重要作用，聚酮合酶（PKS）比非核糖体肽合成酶（例如产生肽的那些）获得较少的关注。我们已经采取了一种新的基因组学方法来研究里氏木霉，深绿木霉和绿色木霉基因组中编码的PKS库。我们的分析奠定了基础，为今后的研究相关的PKSs在木霉属和其他丝状真菌。
Members of the economically important ascomycete genus Trichoderma are ubiquitously distributed around the world. The mycoparasitic lifestyle and plant defence-inducing interactions of Trichoderma spp. make them ideal biocontrol agents. Of the Trichoderma enzymes that produce secondary metabolites, some of which likely play important roles in biocontrol processes, polyketide synthase (PKSs) have garnered less attention than non-ribosomal peptide synthetases such as those that produce peptaibols. We have taken a phylogenomic approach to study the PKS repertoire encoded in the genomes of Trichoderma reesei, Trichoderma atroviride and Trichoderma virens. Our analysis lays a foundation for future research related to PKSs within the genus Trichoderma and in other filamentous fungi.