Complete Genome Sequence of the Treponema pallidum subsp. pallidum Sea81-4 Strain.
Complete Genome Sequence of the Treponema pallidum subsp. pallidum Sea81-4 Strain.
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DOI：
10.1128/genomea.00333-14
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发表时间：
2014-04-17
期刊：
影响因子：
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通讯作者：
Centurion-Lara A
中科院分区：
文献类型：
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作者：
Giacani L;Iverson-Cabral SL;King JC;Molini BJ;Lukehart SA;Centurion-Lara A
采用家兔梅毒模型，对梅毒螺旋体Sea 81 -4株进行了体外培养。已经发现苍白球比其他菌株更可能侵入中枢神经系统（CNS）。为了在基因组水平上确定这种重要表型的可能解释，我们对Sea 81 -4菌株基因组进行了测序。
Using the rabbit model of syphilis, the Sea81-4 strain of Treponema pallidum subsp. pallidum has been found to be more likely than other strains to invade the central nervous system (CNS). To identify possible explanations for this important phenotype at the genomic level, we sequenced the Sea81-4 strain genome.