EARLY DISCORDANT BINOCULAR VISION DISRUPTS SIGNAL TRANSFER IN THE LATERAL GENICULATE-NUCLEUS
EARLY DISCORDANT BINOCULAR VISION DISRUPTS SIGNAL TRANSFER IN THE LATERAL GENICULATE-NUCLEUS
复制标题
DOI：
10.1073/pnas.91.15.6938
复制
发表时间：
1994-07-19
影响因子：
11.1
通讯作者：
SUR, M
中科院分区：
文献类型：
--
作者：
CHINO, YM;CHENG, H;SUR, M
哺乳动物外侧膝状体核(LGN)以一种高度复杂的方式调节从视网膜到大脑新皮质的信号传递。除了来自脑干的输入外，通过皮质膝状体投射和局部抑制性神经元的视网膜外输入还调节了LGN的信号传递。然而，关于LGN信号传递机制的后天发育是否受到早期不协调双眼视觉的影响，我们知之甚少。通过对单个X-LGN细胞和它们的直接视网膜输入之间的反应进行单元内比较，发现由于早期的眼间错位(斜视)，信号传递的效率永久性地降低。与其视网膜输入相比，CAT LGN细胞的对比敏感度和空间分辨率显著降低，信号传输速度显著降低。观察到的生理缺陷与未成熟的X-视黄素生成轴突有关。因此，与之前的想法相反，相互冲突的双眼输入可能会在皮质下视觉结构中产生神经缺陷。
The mammalian lateral geniculate nucleus (LGN) is known to regulate signal transfer from the retina to the brain neocortex in a highly complex manner. Besides inputs from the brainstem, extraretinal inputs via corticogeniculate projections and local inhibitory neurons modulate signal transfer in the LGN. However, very little is known about whether the postnatal development of LGN signal-transfer mechanisms is influenced by early discordant binocular vision. By intraunit comparisons of responses between individual X-LGN cells and their direct retinal inputs, the efficiency of signal transfer was found permanently reduced due to an early interocular misalignment (strabismus). The contrast sensitivity and spatial resolution of cat LGN cells were significantly lower relative to their retinal inputs, and there was substantial decrease in signal-transfer speed. The observed physiological deficits were associated with immature X-retinogeniculate axon arbors. Thus, contrary to previous ideas, conflicting binocular inputs can produce neural deficits in subcortical visual structures.