Mild memory impairment in healthy older adults is distinct from normal aging
Mild memory impairment in healthy older adults is distinct from normal aging
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DOI：
10.1016/j.bandc.2005.10.004
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发表时间：
2006-03-01
影响因子：
2.5
通讯作者：
Masters, C
中科院分区：
文献类型：
--
作者：
Cargin, JW;Maruff, P;Masters, C
使用单词列表学习任务的延迟回忆试验，在健康社区居住的老年人样本中，28% 的人发现了轻度记忆障碍。统计分析显示，记忆障碍患者在其他记忆测量、执行功能测试、处理速度和整体认知方面也表现出相对缺陷，这些测试是通过 CERAD 和 Cog-State 电池以及 CANTAB 配对关联学习任务进行测量的。这些相对缺陷不能用年龄相关的变化、教育、智力、情绪、健康相关因素或个体的 ApoE epsilon 4 状态来解释。记忆受损的个体（n = 30）没有意识到他们的记忆和认知困难的程度超出了研究中正常老年人（n = 77）表达的一般抱怨，并且他们的明显困难似乎并没有影响他们参与生活活动。这些发现表明，轻度记忆障碍个体表现出的记忆和认知困难不太可能反映正常衰老。相反，这种损伤可能预示着值得进一步研究的早期神经退行性过程。 (c) 2005 Elsevier Inc. 保留所有权利。
Mild memory impairment was detected in 28% of a sample of healthy community-dwelling older adults using the delayed recall trial of a word list learning task. Statistical analysis revealed that individuals with memory impairment also demonstrated relative deficits on other measures of memory, and tests of executive function, processing speed and global cognition, as measured by the CERAD and Cog-State batteries and CANTAB paired associate learning task. These relative deficits cannot be explained by age-related changes, education, intelligence, mood, health-related factors, or the individuals' ApoE epsilon 4 status. Memory-impaired individuals (n = 30) did not recognize the extent of their memory and cognitive difficulties beyond the general complaints expressed by normal elderly (n = 77) within the study and their apparent difficulties did not appear to impact on their participation in life activities. These findings suggest it is unlikely that the memory and cognitive difficulties demonstrated by individuals with mild memory impairment reflect normal aging. Rather it is possible that such impairment may signal early neurodegenerative processes worthy of further investigation. (c) 2005 Elsevier Inc. All rights reserved.