Postnatal Development of Proteins Associated with Different Benzodiazepine Receptors
Postnatal Development of Proteins Associated with Different Benzodiazepine Receptors
复制标题
与不同苯二氮卓受体相关的蛋白质的产后发育
DOI：
10.1111/j.1471-4159.1986.tb12941.x
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发表时间：
1986
影响因子：
4.7
通讯作者：
W. Sieghart
中科院分区：
文献类型：
--
作者：
A. Eichinger;W. Sieghart
摘要：本文研究了大鼠大脑皮质膜上几种氟硝西泮不可逆标记蛋白质的生后发育。结果表明，在出生后早期，表观分子量为55，000和59，000的蛋白质主要被标记，而表观分子量为51，000的蛋白质的不可逆标记仅在出生后第二周开始占主导地位。在整个发育过程中，另一种表观分子量为62，000的蛋白质的不可逆标记较弱。所有这些蛋白质似乎都与中枢苯二氮卓受体有关。出生后不同时间点的不可逆标记似乎与这些蛋白质的出生后发育平行，并且不同的发育时间过程和个体蛋白质的不同结合特性支持这些蛋白质与单独和不同的苯二氮卓类受体亚型相关的假设。个体受体亚型的药理学性质似乎在出生后早期就完全发育，因此新生动物似乎是研究这些各种苯二氮卓类受体亚型的性质和功能的良好模型系统。
Abstract: The postnatal development of several proteins irreversibly labeled by [3H]flunitrazepam in membranes from rat cerebral cortex was investigated. It was demonstrated that in the early postnatal days proteins with apparent molecular weights 55,000 and 59,000 were predominantly labeled whereas irreversible labeling of a protein with apparent molecular weight 51,000 started to predominate only in the second postnatal week. Irreversible labeling of another protein with apparent molecular weight 62,000 was weak throughout development. All these proteins seem to be associated with central benzodiazepine receptors. Irreversible labeling at various time points after birth seems to parallel the postnatal development of these proteins, and the different time course of development and different binding properties of theindividual proteins support the hypothesis that these proteins are associated with separate and distinct benzodiazepine receptor subtypes. The pharmacological properties of the individual receptor subtypes seem to be fully developed in the early postnatal days, and therefore newborn animals seem to be a good model system for the investigation of properties and function of these various benzodiazepine receptor subtypes.
影响因子：
5
作者：
Toll,L;Keys,C;Spangler,D;Loew,G
通讯作者：
Loew,G