Prevalence and prognostic significance of the presence of esophageal varices in patients with hepatocellular carcinoma
Prevalence and prognostic significance of the presence of esophageal varices in patients with hepatocellular carcinoma
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DOI：
10.1016/j.cgh.2006.08.011
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发表时间：
2006-11-01
影响因子：
12.6
通讯作者：
Caturelli, Eugenio
中科院分区：
文献类型：
--
作者：
Giannini, Edoardo Giovanni;Risso, Domenico;Caturelli, Eugenio
背景和目标：临床相关的门静脉高压可能影响肝细胞癌（HCC）患者的治疗和预后。然而，食管静脉曲张在这些患者中的存在的重要性尚未得到正式解决。在这项研究中，我们的目的是评估食管静脉曲张的患病率和预后的相关性，在一个大型系列的肝癌患者。研究方法：食管静脉曲张的患病率在1153例HCC患者中进行了评估，这些患者连续转诊至10个意大利中心（意大利肝癌组）。生存期计算从HCC诊断到死亡或到最近一次随访访视，并根据是否存在食管静脉曲张进行评估。在多因素回归分析中进一步评估了食管静脉曲张存在的独立预后意义。结果：食管静脉曲张730例（63.3%）。静脉曲张患者的生存时间明显缩短（P
Background & Aims: It has been suggested that clinically relevant portal hypertension may affect the therapeutic management and prognosis of cirrhotic patients with hepatocellular carcinoma (HCC). Nevertheless, the importance of the presence of esophageal varices in these patients has not yet been addressed formally. in this study our aim was to evaluate the prevalence and prognostic relevance of the presence of esophageal varices in a large series of patients with HCC. Methods: The prevalence of esophageal varices was evaluated in 1153 HCC patients who were consecutively referred to 10 Italian centers (the Italian Liver Cancer group). Survival was calculated from the time of HCC diagnosis until death or until the most recent follow-up visit, and was evaluated according to the presence or absence of esophageal varices. The independent prognostic meaning of the presence of esophageal varices was evaluated further in a multivariate regression analysis. Results: Esophageal varices were found in 730 patients (63.3%). Patients with varices showed significantly shorter survival times (P