Shared distal regulatory regions may contribute to the coordinated expression of human ribosomal protein genes
Shared distal regulatory regions may contribute to the coordinated expression of human ribosomal protein genes
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DOI：
10.1016/j.ygeno.2020.03.028
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发表时间：
2020-07-01
期刊：
影响因子：
4.4
通讯作者：
Li，Xiaoman
中科院分区：
文献类型：
--
作者：
Wang，Saidi;Hu，Haiyan;Li，Xiaoman
为了鉴定人核糖体蛋白基因（RPGs）的潜在远端调控区并了解其特征，我们研究了7种细胞系和4种主要细胞类型中的染色质相互作用。我们鉴定了22，797个与人类RPG启动子直接或间接相互作用的推定调控区域。这些区域中的大部分仅存在于一种细胞系或一种细胞类型中，这意味着RPGs可能在实验条件下受到差异调节。我们还注意到，不同细胞系和细胞类型的RPG组是相同的，它们共享共同的调控区域。这些共同的调节区域的RPG可能有助于他们的协调调节。通过研究已鉴定的调控区域中过度表达的基序，我们发现这些区域中约有24个基序在细胞系和细胞类型中共享。我们的研究为人类RPGs的协调转录调控提供了新的线索。
To identify the potential distal regulatory regions of human ribosomal protein genes (RPGs) and to understand their characteristics, we studied the chromatin interactions in seven cell lines and four primary cell types. We identified 22,797 putative regulatory regions that directly or indirectly interact with human RPG promoters. A large proportion of these regions are only present in one cell line or one cell type, implying that RPGs may be differentially regulated across experimental conditions. We also noticed that groups of RPGs, which are the same groups across cell lines and cell types, share common regulatory regions. These shared regulatory regions by RPGs may contribute to their coordinated regulation. By studying the overrepresented motifs in the identified regulatory regions, we showed that there are about two dozen motifs in these regions shared across cell lines and cell types. Our study shed new light on the coordinated transcriptional regulation of human RPGs.