Vertebral Compression Fracture (VCF) After Spine Stereotactic Body Radiation Therapy (SBRT): Analysis of Predictive Factors
Vertebral Compression Fracture (VCF) After Spine Stereotactic Body Radiation Therapy (SBRT): Analysis of Predictive Factors
复制标题
DOI：
10.1016/j.ijrobp.2012.04.034
复制
发表时间：
2012-11-01
影响因子：
7
通讯作者：
Sahgal, Arjun
中科院分区：
文献类型：
--
作者：
Cunha, Marcelo V. R.;Al-Omair, Ameen;Sahgal, Arjun
目的：脊柱立体定向全身放射治疗(SBRT)后，椎体压缩骨折(VCFs)的发生率越来越高。这项研究的目的是确定脊柱SBRT后VCF的风险，并确定预测VCF的临床和剂量学因素。该分析纳入了最近公布的脊柱不稳定肿瘤评分(SINS)标准。方法和材料：本研究的主要终点是在SBRT治疗后出现新的VCF(即新的终板骨折或塌陷畸形)或基于治疗部位现有骨折的骨折进展。我们根据6项SINS标准对接受脊柱SBRT治疗的90名患者的167个脊柱节段进行了回顾性评分。我们还评估了脊柱旁伸展的存在、先前的放射、各种剂量学参数，包括每部分的剂量(>；=20Gyvs
Purpose: Vertebral compression fractures (VCFs) are increasingly observed after spine stereotactic body radiation therapy (SBRT). The aim of this study was to determine the risk of VCF after spine SBRT and identify clinical and dosimetric factors predictive for VCF. The analysis incorporated the recently described Spinal Instability Neoplastic Score (SINS) criteria.Methods and Materials: The primary endpoint of this study was the development of a de novo VCF (ie, new endplate fracture or collapse deformity) or fracture progression based on an existing fracture at the site of treatment after SBRT. We retrospectively scored 167 spinal segments in 90 patients treated with spine SBRT according to each of the 6 SINS criteria. We also evaluated the presence of paraspinal extension, prior radiation, various dosimetric parameters including dose per fraction (>= 20 Gy vs