Newly acquired right bundle-branch block: The Framingham Study.
Newly acquired right bundle-branch block: The Framingham Study.
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DOI：
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发表时间：
1980
影响因子：
39.2
通讯作者：
J. Schneider;H. Thomas;B. Kreger;P. McNamara;P. Sorlie;W. Kannel
中科院分区：
文献类型：
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作者：
J. Schneider;H. Thomas;B. Kreger;P. McNamara;P. Sorlie;W. Kannel
在Framingham研究中，在18年的两年随访中，所有70名发展为完全性右束支传导阻滞(RBBB)的患者都被前瞻性地识别出心血管异常。大多数人在RBBB出现之前就已是高血压患者。虽然RBBB的最初出现通常不伴有明显的临床事件，但随后的冠状动脉疾病和充血性衰竭的发生率分别是没有RBBB的匹配对照组的2.5倍和1.5倍和4倍。在患有RBBB的人群中，心血管疾病死亡率几乎是年龄匹配的普通人群样本中的三倍。心血管疾病死亡率的过高主要与相关心血管异常的高患病率有关。只有21%的患者没有出现临床上明显的心血管异常。QRS间期大于或等于130ms，QRS轴在-45度和-90度之间的人最有可能有相关的心血管异常。
Cardiovascular abnormalities were identified prospectively in all 70 persons who developed complete right bundle-branch block (RBBB) in The Framingham Study during 18 years of biennial follow-up. Most were hypertensive before the appearance of RBBB. Although the initial appearance of RBBB was usually unaccompanied by overt clinical events, the subsequent incidence of coronary disease and congestive failure was two and one-half and four times greater, respectively, than that in matched control subjects without RBBB. The incidence of cardiovascular disease mortality was almost three times greater in persons who developed RBBB than in an age-matched sample of the population-at-large. This excess of cardiovascular disease mortality was related primarily to the high prevalence of associated cardiovascular abnormalities. Only 21% remained free from clinically apparent cardiovascular abnormalities. A QRS duration of greater than or equal to 130 ms and a QRS axis between -45 degrees and -90 degrees identified those most likely to have associated cardiovascular abnormalities.