CSF SOMATOSTATIN INCREASE IN PATIENTS WITH EARLY PARKINSONIAN-SYNDROME
CSF SOMATOSTATIN INCREASE IN PATIENTS WITH EARLY PARKINSONIAN-SYNDROME
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DOI：
10.1007/bf02259660
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发表时间：
1995-01-01
期刊：
影响因子：
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通讯作者：
NAVARRO, MA
中科院分区：
文献类型：
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作者：
ESPINO, A;CALOPA, M;NAVARRO, MA
对23例未经治疗的帕金森综合征患者（15例原发性帕金森病（IPD）和8例其他形式的帕金森综合征）在临床诊断时（平均病程1.1 ± 0.2年）和26例无神经系统症状的受试者的脑脊液（CSF）中生长抑素样免疫反应性水平（SLI）进行了测定。在纳入研究时，没有一名IPD患者被诊断为痴呆。发现帕金森综合征患者的CSF-SLI含量（107.9 +/- 9.8 pg/ml）显著高于对照受试者（73.5 +/- 8.4 pg/ml）。当对照组与IPD患者相比时，这种增加也是显著的。此外，所有患者脑脊液中SLI与高香草酸呈正相关。学习记忆的测试被用来评估患者的精神状态和CSF-生长抑素水平显着增加，观察到特发性帕金森病和严重的记忆障碍患者。这些结果表明，在未经治疗的帕金森综合征的早期阶段，脑脊液中的生长抑素浓度可能会增加，可能是由于纹状体或皮质神经元的生长抑素的神经退行性耗竭。
Somatostatin-like immunoreactivity levels (SLI) in cerebrospinal fluid (CSF) were determined in twenty-three patients with untreated parkinsonian syndrome (15 with Idiopathic Parkinson's disease (IPD) and 8 with other forms of parkinsonism) at the moment of clinical diagnosis (mean duration of disease 1.1 +/- 0.2 years), and in 26 subjects without neurological symptoms. None of the IPD patients had a diagnosis of dementia at the moment of inclusion in the study. CSF-SLI content was found to be significantly higher in patients with parkinsonian syndrome (107.9 +/- 9.8 pg/ml) than in control subjects (73.5 +/- 8.4 pg/ml). The increase was also significant when controls were compared with IPD patients. In addition, a positive correlation between SLI and homovanillic acid was found in CSF of all patients. A test of learning memory was used to evaluate the mental state of patients and a significant increase in CSF-somatostatin levels was observed in patients with Idiopathic Parkinson's disease and severe affectation of memory. These results indicate that in the early steps of untreated parkinsonian syndrome, somatostatin concentration in cerebrospinal fluid may increase, probably due to the neurodegenerative depletion of somatostatin from striatal or cortical neurons.