Early disruption of plasticity the mother-infant relationship: effects on brain and implications for psychopathology
Early disruption of plasticity the mother-infant relationship: effects on brain and implications for psychopathology
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DOI：
10.1016/s0149-7634(03)00010-1
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发表时间：
2003-01-01
影响因子：
8.2
通讯作者：
Alleva, E
中科院分区：
文献类型：
--
作者：
Cirulli, F;Berry, A;Alleva, E
早期的环境操纵可以影响发育中的神经系统，有助于形成对环境挑战的生理和行为反应的个体差异。特别是，已经表明，母婴关系的中断会导致成年生物体的神经内分泌、神经化学和行为变化，尽管这种变化的基本机制尚未完全阐明。最近的数据表明，神经营养因子可能是能够转导外部操作对大脑发育的影响的介质之一。已知神经生长因子和脑源性神经营养因子在脑发育过程中起主要作用，而在成年动物中，它们主要负责维持神经元功能和结构完整性。神经营养因子水平的变化在关键的发展阶段可能会导致长期的变化，神经元的可塑性，并导致衰老和精神病理学的脆弱性增加。(C)2003爱思唯尔科技有限公司版权所有。
Early environmental manipulations can impact on the developing nervous system, contributing to shape individual differences in physiological and behavioral responses to environmental challenges. In particular, it has been shown that disruptions in the mother-infant relationship result in neuroendocrine, neurochemical and behavioural changes in the adult organism, although the basic mechanisms underlying such changes have not been completely elucidated. Recent data suggest that neurotrophins might be among the mediators capable of transducing the effects of external manipulations on brain development. Nerve growth factor and brain-derived neurotrophic factor are known to play a major role during brain development, while in the adult animal they are mainly responsible for the maintenance of neuronal function and structural integrity. Changes in the levels of neurotrophic factors during critical developmental stages might result in long-term changes in neuronal plasticity and lead to increased vulnerability to aging and to psychopathology. (C) 2003 Elsevier Science Ltd. All rights reserved.