Poly(2-oxazoline)-derived Contact Biocides: Contributions to the Understanding of Antimicrobial Activity
Poly(2-oxazoline)-derived Contact Biocides: Contributions to the Understanding of Antimicrobial Activity
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DOI：
10.1002/mabi.201200240
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发表时间：
2013-01-01
影响因子：
4.6
通讯作者：
Wiesbrock, Frank
中科院分区：
文献类型：
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作者：
Kelly, Andrew M.;Kaltenhauser, Verena;Wiesbrock, Frank
通过微波辅助聚合和酸介导水解制备了一组聚（2-恶唑啉）衍生（共）聚合物，并在50x50x2mm含5？Wt %的聚合物。对革兰氏阴性大肠杆菌、铜绿假单胞菌和白色念珠菌的抑菌活性仅依赖于水解程度，而对革兰氏阳性金黄色葡萄球菌的抑菌活性仅观察到水解的聚（2-壬基-2-恶唑啉）s。与纯PP相比，复合板的表面能几乎没有变化，这些化合物可以被认为是PP的替代品。PP复合板表面存在杀菌剂添加剂，可以通过ATR-IR， zeta电位和SEM-EDX测量来显示。在PP复合板中添加1%的杀菌剂后，在两次孵育过程中仍能保持抗菌活性。
A set of poly(2-oxazoline)-derived (co-)polymers was prepared by microwave-assisted polymerizations and acid-mediated hydrolysis and tested for antimicrobial activity in 50x50x2mm PP compound plates containing 5?wt% of the polymers. Antimicrobial activity against gram-negative E. coli and P. aeruginosa as well as C. albicans depended only on the degree of hydrolysis, while antimicrobial activity against gram-positive S. aureus was only observed for hydrolyzed poly(2-nonyl-2-oxazoline)s. The surface energies of the compound plates compared to pure PP were hardly altered, and the compounds can be considered as alternatives for PP. The presence of the biocide additives at the surface of the PP compound plates could be shown by combined ATR-IR, zeta potential, and SEM-EDX measurements. Antimicrobial activity was maintained during double incubation as well as for lowered amounts of the biocide additive of 1% in PP compound plates.