Wet-spun poly(ε-caprolactone) microfiber scaffolds for oriented growth and infiltration of smooth muscle cells
Wet-spun poly(ε-caprolactone) microfiber scaffolds for oriented growth and infiltration of smooth muscle cells
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DOI：
10.1016/j.matlet.2014.06.038
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发表时间：
2014-10-01
影响因子：
3
通讯作者：
Kong, Deling
中科院分区：
文献类型：
--
作者：
Zhang, Jiamin;Wang, Lina;Kong, Deling
组织工程血管需要定向纤维支架作为模板来引导平滑肌细胞（SMC）定向生长和浸润。制造这种纤维支架是一个相当大的挑战。在这封信中，我们开发了一种新的湿纺系统，该系统使用食用油和己烷的混合溶液作为非溶剂凝固浴来制造定向聚（ε-己内酯）（PCL）微纤维支架。纤维直径和孔隙率可分别控制在7～27μm和68～82％的范围内。 SMC 可以沿着纤维定向生长并渗透到支架内部并保持 SMC 表型。这种定向微纤维支架在血管和其他纤维组织（如肌腱、韧带和椎间盘）再生方面具有广阔的前景。 (C) 2014 Elsevier B.V. 保留所有权利。
The tissue engineered blood vessel requires oriented fibrous scaffold as template to guide smooth muscle cells (SMCs) oriented growth and infiltration. It is a considerable challenge to fabricate this kind of fibrous scaffold. In this letter, we developed a new wet-spinning system that involves a blended solution of edible oil and hexane as a non-solvent coagulation bath to fabricate oriented poly(epsilon-caprolactone) (PCL) microfiber scaffold. The fiber diameter and porosity could be controlled in the range of 7 to 27 mu m and 68 to 82%, respectively. SMCs could grow in an oriented fashion along the fibers and infiltrate inside the scaffold as well as maintain SMCs phenotype. This oriented microfiber scaffold has a promising potential for regenerating blood vessels and other fibrous tissues such as tendon, ligament and intervertebral discs. (C) 2014 Elsevier B.V. All rights reserved.