Plasma B-type natriuretic peptide study in children with severe enterovirus 71 infection: a pilot study
Plasma B-type natriuretic peptide study in children with severe enterovirus 71 infection: a pilot study
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DOI：
10.1016/j.ijid.2013.06.012
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发表时间：
2013-12-01
影响因子：
8.4
通讯作者：
Hwang, Betau
中科院分区：
文献类型：
--
作者：
Jan, Sheng-Ling;Lin, Shing-Jong;Hwang, Betau
目的：肠道病毒71型（EV71）严重感染儿童可导致急性心力衰竭。B型利钠肽（BNP）是一种良好的心肌应激生物标志物。方法：将EV71感染患者分为3组：正常对照组（n = 30）、EV71感染合并中枢神经系统损害组（n = 20）、EV71感染合并心肺功能衰竭组（n = 3），并与健康对照组进行比较。结果：第2组患者均痊愈，无神经系统后遗症，第3组患者均存活，无心脏并发症。第3组患者的肌钙蛋白I、肌酸激酶MB分数和BNP水平高于其他组。BNP中位数为
Objectives: Severe enterovirus 71 (EV71) infections in children can result in acute heart failure. B-type natriuretic peptide (BNP) is a good biomarker of myocardial stress. The purpose of this study was to use plasma BNP for the detection of EV71 infection with cardiac involvement.Methods: Patients with severe EV71 infections and healthy control subjects were studied: group 1 (n = 30), normal controls; group 2 (n = 20), EV71 infection with central nervous system involvement; and group 3 (n = 3), EV71 infection with cardiopulmonary failure. The demographic and laboratory data including plasma BNP levels were analyzed statistically.Results: All group 2 patients recovered completely without neurological sequelae, and all group 3 patients survived without cardiac complications. Group 3 patients had higher troponin I, MB fraction of creatine kinase, and BNP levels than patients of the other groups. The median BNP values were