Chemogenetic disconnection of monkey orbitofrontal and rhinal cortex reversibly disrupts reward value.
Chemogenetic disconnection of monkey orbitofrontal and rhinal cortex reversibly disrupts reward value.
复制标题
DOI：
10.1038/nn.4192
复制
发表时间：
2016-01
影响因子：
25
通讯作者：
Richmond BJ
中科院分区：
文献类型：
--
作者：
Eldridge MA;Lerchner W;Saunders RC;Kaneko H;Krausz KW;Gonzalez FJ;Ji B;Higuchi M;Minamimoto T;Richmond BJ
为了研究眶额皮质（OFC）和鼻周皮质（Rh）之间的相互作用如何影响对奖励大小的判断，我们使用hM4Di - DREADD（由设计药物特异性激活的设计受体）可逆地切断了这些区域之间的联系。反复失活降低了两只猴子对奖励大小差异的敏感性。结果表明，从记忆中提取相对刺激值似乎取决于鼻周皮质和眶额皮质之间的相互作用。
To study how the interaction between orbitofrontal (OFC) and rhinal (Rh) cortices influences the judgment of reward size, we reversibly disconnected these regions using the hM4Di-DREADD (Designer Receptor Exclusively Activated by Designer Drug). Repeated inactivation reduced sensitivity to differences in reward size in two monkeys. Results suggest that retrieval of relative stimulus values from memory appears to depend on interaction between Rh and OFC.