New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.
New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.
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DOI：
10.1038/ng.2477
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发表时间：
2013-01
期刊：
影响因子：
30.8
通讯作者：
Freathy, Rachel M.
中科院分区：
文献类型：
--
作者：
Horikoshi, Momoko;Yaghootkar, Hanieh;Mook-Kanamori, Dennis O.;Sovio, Ulla;Taal, H. Rob;Hennig, Branwen J.;Bradfield, Jonathan P.;St Pourcain, Beate;Evans, David M.;Charoen, Pimphen;Kaakinen, Marika;Cousminer, Diana L.;Lehtimaki, Terho;Kreiner-Moller, Eskil;Warrington, Nicole M.;Bustamante, Mariona;Feenstra, Bjarke;Berry, Diane J.;Thiering, Elisabeth;Pfab, Thiemo;Barton, Sheila J.;Shields, Beverley M.;Kerkhof, Marjan;van Leeuwen, Elisabeth M.;Fulford, Anthony J.;Kutalik, Zoltan;Zhao, Jing Hua;den Hoed, Marcel;Mahajan, Anubha;Lindi, Virpi;Goh, Liang-Kee;Hottenga, Jouke-Jan;Wu, Ying;Raitakari, Olli T.;Harder, Marie N.;Meirhaeghe, Aline;Ntalla, Ioanna;Salem, Rany M.;Jameson, Karen A.;Zhou, Kaixin;Monies, Dorota M.;Lagou, Vasiliki;Kirin, Mirna;Heikkinen, Jani;Adair, Linda S.;Alkuraya, Fowzan S.;Al-Odaib, Ali;Amouyel, Philippe;Andersson, Ehm Astrid;Bennett, Amanda J.;Blakemore, Alexandra I. F.;Buxton, Jessica L.;Dallongeville, Jean;Das, Shikta;de Geus, Eco J. C.;Estivill, Xavier;Flexeder, Claudia;Froguel, Philippe;Geller, Frank;Godfrey, Keith M.;Gottrand, Frederic;Groves, Christopher J.;Hansen, Torben;Hirschhorn, Joel N.;Hofman, Albert;Hollegaard, Mads V.;Hougaard, David M.;Hyppoenen, Elina;Inskip, Hazel M.;Isaacs, Aaron;Jorgensen, Torben;Kanaka-Gantenbein, Christina;Kemp, John P.;Kiess, Wieland;Kilpelainen, Tuomas O.;Klopp, Norman;Knight, Bridget A.;Kuzawa, Christopher W.;McMahon, George;Newnham, John P.;Niinikoski, Harri;Oostra, Ben A.;Pedersen, Louise;Postma, Dirkje S.;Ring, Susan M.;Rivadeneira, Fernando;Robertson, Neil R.;Sebert, Sylvain;Simell, Olli;Slowinski, Torsten;Tiesler, Carla M. T.;Toenjes, Anke;Vaag, Allan;Viikari, Jorma S.;Vink, Jacqueline M.;Vissing, Nadja Hawwa;Wareham, Nicholas J.;Willemsen, Gonneke;Witte, Daniel R.;Zhang, Haitao;Zhao, Jianhua;Wilson, James F.;Stumvoll, Michael;Prentice, Andrew M.;Meyer, Brian F.;Pearson, Ewan R.;Boreham, Colin A. G.;Cooper, Cyrus;Gillman, Matthew W.;Dedoussis, George V.;Moreno, Luis A.;Pedersen, Oluf;Saarinen, Maiju;Mohlke, Karen L.;Boomsma, Dorret I.;Saw, Seang-Mei;Lakka, Timo A.;Koerner, Antje;Loos, Ruth J. F.;Ong, Ken K.;Vollenweider, Peter;van Duijn, Cornelia M.;Koppelman, Gerard H.;Hattersley, Andrew T.;Holloway, John W.;Hocher, Berthold;Heinrich, Joachim;Power, Chris;Melbye, Mads;Guxens, Monica;Pennell, Craig E.;Bonnelykke, Klaus;Bisgaard, Hans;Eriksson, Johan G.;Widen, Elisabeth;Hakonarson, Hakon;Uitterlinden, Andre G.;Pouta, Anneli;Lawlor, Debbie A.;Smith, George Davey;Frayling, Timothy M.;McCarthy, Mark I.;Grant, Struan F. A.;Jaddoe, Vincent W. V.;Jarvelin, Marjo-Riitta;Timpson, Nicholas J.;Prokopenko, Inga;Freathy, Rachel M.
正常范围内的出生体重与多种成人发病疾病有关，但这些关联背后的机制尚不清楚。先前的全基因组关联研究发现，ADCY5基因的一个变体与出生体重和2型糖尿病都相关，第二个变体靠近CCNL1，与成年特征没有明显联系。在一项扩展的全基因组关联荟萃分析和随访研究中（来自43项研究的69,308名欧洲血统个体），我们现在将全基因组显著位点的数量扩大到7个，这与母亲吸烟的方差比例相似。已知其中五个位点与其他表型相关：ADCY5和CDKAL1与2型糖尿病有关；ADRB1与成人血压有关；HMGA2和LCORL与成人身高呈正相关。我们的发现强调了胎儿生长与出生后生长和新陈代谢之间的遗传联系。
Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood. Previous genome-wide association studies identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes, and a second variant, near CCNL1, with no obvious link to adult traits. In an expanded genome-wide association meta-analysis and follow-up study (up to 69,308 individuals of European descent from 43 studies), we have now extended the number of genome-wide significant loci to seven, accounting for a similar proportion of variance to maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes; ADRB1 with adult blood pressure; and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism.
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影响因子：
64.8
作者：
Ehret, Georg B.;Munroe, Patricia B.;Rice, Kenneth M.;Bochud, Murielle;Johnson, Andrew D.;Chasman, Daniel I.;Smith, Albert V.;Tobin, Martin D.;Verwoert, Germaine C.;Hwang, Shih-Jen;Pihur, Vasyl;Vollenweider, Peter;O'Reilly, Paul F.;Amin, Najaf;Bragg-Gresham, Jennifer L.;Teumer, Alexander;Glazer, Nicole L.;Launer, Lenore;Zhao, Jing Hua;Aulchenko, Yurii;Heath, Simon;Sober, Siim;Parsa, Afshin;Luan, Jian'an;Arora, Pankaj;Dehghan, Abbas;Zhang, Feng;Lucas, Gavin;Hicks, Andrew A.;Jackson, Anne U.;Peden, John F.;Tanaka, Toshiko;Wild, Sarah H.;Rudan, Igor;Igl, Wilmar;Milaneschi, Yuri;Parker, Alex N.;Fava, Cristiano;Chambers, John C.;Fox, Ervin R.;Kumari, Meena;Go, Min Jin;van der Harst, Pim;Kao, Wen Hong Linda;Sjogren, Marketa;Vinay, D. G.;Alexander, Myriam;Tabara, Yasuharu;Shaw-Hawkins, Sue;Whincup, Peter H.;Liu, Yongmei;Shi, Gang;Kuusisto, Johanna;Tayo, Bamidele;Seielstad, Mark;Sim, Xueling;Khanh-Dung Hoang Nguyen;Lehtimaki, Terho;Matullo, Giuseppe;Wu, Ying;Gaunt, Tom R.;Onland-Moret, N. Charlotte;Cooper, Matthew N.;Platou, Carl G. P.;Org, Elin;Hardy, Rebecca;Dahgam, Santosh;Palmen, Jutta;Vitart, Veronique;Braund, Peter S.;Kuznetsova, Tatiana;Uiterwaal, Cuno S. P. M.;Adeyemo, Adebowale;Palmas, Walter;Campbell, Harry;Ludwig, Barbara;Tomaszewski, Maciej;Tzoulaki, Ioanna;Palmer, Nicholette D.;Aspelund, Thor;Garcia, Melissa;Chang, Yen-Pei C.;O'Connell, Jeffrey R.;Steinle, Nanette I.;Grobbee, Diederick E.;Arking, Dan E.;Kardia, Sharon L.;Morrison, Alanna C.;Hernandez, Dena;Najjar, Samer;McArdle, Wendy L.;Hadley, David;Brown, Morris J.;Connell, John M.;Hingorani, Aroon D.;Day, Ian N. M.;Lawlor, Debbie A.;Beilby, John P.;Lawrence, Robert W.;Clarke, Robert;Hopewell, Jemma C.;Ongen, Halit;Dreisbach, Albert W.;Li, Yali;Young, J. Hunter;Bis, Joshua C.;Kahonen, Mika;Viikari, Jorma;Adair, Linda S.;Lee, Nanette R.;Chen, Ming-Huei;Olden, Matthias;Pattaro, Cristian;Bolton, Judith A. Hoffman;Koettgen, Anna;Bergmann, Sven;Mooser, Vincent;Chaturvedi, Nish;Frayling, Timothy M.;Islam, Muhammad;Jafar, Tazeen H.;Erdmann, Jeanette;Kulkarni, Smita R.;Bornstein, Stefan R.;Graessler, Juergen;Groop, Leif;Voight, Benjamin F.;Kettunen, Johannes;Howard, Philip;Taylor, Andrew;Guarrera, Simonetta;Ricceri, Fulvio;Emilsson, Valur;Plump, Andrew;Barroso, Ine S.;Khaw, Kay-Tee;Weder, Alan B.;Hunt, Steven C.;Sun, Yan V.;Bergman, Richard N.;Collins, Francis S.;Bonnycastle, Lori L.;Scott, Laura J.;Stringham, Heather M.;Peltonen, Leena;Perola, Markus;Vartiainen, Erkki;Brand, Stefan-Martin;Staessen, Jan A.;Wang, Thomas J.;Burton, Paul R.;Artigas, Maria Soler;Dong, Yanbin;Snieder, Harold;Wang, Xiaoling;Zhu, Haidong;Lohman, Kurt K.;Rudock, Megan E.;Heckbert, Susan R.;Smith, Nicholas L.;Wiggins, Kerri L.;Doumatey, Ayo;Shriner, Daniel;Veldre, Gudrun;Viigimaa, Margus;Kinra, Sanjay;Prabhakaran, Dorairaj;Tripathy, Vikal;Langefeld, Carl D.;Rosengren, Annika;Thelle, Dag S.;Corsi, Anna Maria;Singleton, Andrew;Forrester, Terrence;Hilton, Gina;McKenzie, Colin A.;Salako, Tunde;Iwai, Naoharu;Kita, Yoshikuni;Ogihara, Toshio;Ohkubo, Takayoshi;Okamura, Tomonori;Ueshima, Hirotsugu;Umemura, Satoshi;Eyheramendy, Susana;Meitinger, Thomas;Wichmann, H. -Erich;Cho, Yoon Shin;Kim, Hyung-Lae;Lee, Jong-Young;Scott, James;Sehmi, Joban S.;Zhang, Weihua;Hedblad, Bo;Nilsson, Peter;Smith, George Davey;Wong, Andrew;Narisu, Narisu;Stancakova, Alena;Raffel, Leslie J.;Yao, Jie;Kathiresan, Sekar;O'Donnell, Christopher J.;Schwartz, Stephen M.;Ikram, M. Arfan;Longstreth, W. T., Jr.;Mosley, Thomas H.;Seshadri, Sudha;Shrine, Nick R. G.;Wain, Louise V.;Morken, Mario A.;Swift, Amy J.;Laitinen, Jaana;Prokopenko, Inga;Zitting, Paavo;Cooper, Jackie A.;Humphries, Steve E.;Danesh, John;Rasheed, Asif;Goel, Anuj;Hamsten, Anders;Watkins, Hugh;Bakker, Stephan J. L.;van Gilst, Wiek H.;Janipalli, Charles S.;Mani, K. Radha;Yajnik, Chittaranjan S.;Hofman, Albert;Mattace-Raso, Francesco U. S.;Oostra, Ben A.;Demirkan, Ayse;Isaacs, Aaron;Rivadeneira, Fernando;Lakatta, Edward G.;Orru, Marco;Scuteri, Angelo;Ala-Korpela, Mika;Kangas, Antti J.;Lyytikainen, Leo-Pekka;Soininen, Pasi;Tukiainen, Taru;Wurtz, Peter;Ong, Rick Twee-Hee;Doerr, Marcus;Kroemer, Heyo K.;Voelker, Uwe;Voelzke, Henry;Galan, Pilar;Hercberg, Serge;Lathrop, Mark;Zelenika, Diana;Deloukas, Panos;Mangino, Massimo;Spector, Tim D.;Zhai, Guangju;Meschia, James F.;Nalls, Michael A.;Sharma, Pankaj;Terzic, Janos;Kumar, M. V. Kranthi;Denniff, Matthew;Zukowska-Szczechowska, Ewa;Wagenknecht, Lynne E.;Fowkes, F. Gerald R.;Charchar, Fadi J.;Schwarz, Peter E. H.;Hayward, Caroline;Guo, Xiuqing;Rotimi, Charles;Bots, Michiel L.;Brand, Eva;Samani, Nilesh J.;Polasek, Ozren;Talmud, Philippa J.;Nyberg, Fredrik;Kuh, Diana;Laan, Maris;Hveem, Kristian;Palmer, Lyle J.;van der Schouw, Yvonne T.;Casas, Juan P.;Mohlke, Karen L.;Vineis, Paolo;Raitakari, Olli;Ganesh, Santhi K.;Wong, Tien Y.;Tai, E. Shyong;Cooper, Richard S.;Laakso, Markku;Rao, Dabeeru C.;Harris, Tamara B.;Morris, Richard W.;Dominiczak, Anna F.;Kivimaki, Mika;Marmot, Michael G.;Miki, Tetsuro;Saleheen, Danish;Chandak, Giriraj R.;Coresh, Josef;Navis, Gerjan;Salomaa, Veikko;Han, Bok-Ghee;Zhu, Xiaofeng;Kooner, Jaspal S.;Melander, Olle;Ridker, Paul M.;Bandinelli, Stefania;Gyllensten, Ulf B.;Wright, Alan F.;Wilson, James F.;Ferrucci, Luigi;Farrall, Martin;Tuomilehto, Jaakko;Pramstaller, Peter P.;Elosua, Roberto;Soranzo, Nicole;Sijbrands, Eric J. G.;Altshuler, David;Loos, Ruth J. F.;Shuldiner, Alan R.;Gieger, Christian;Meneton, Pierre;Uitterlinden, Andre G.;Wareham, Nicholas J.;Gudnason, Vilmundur;Rotter, Jerome I.;Rettig, Rainer;Uda, Manuela;Strachan, David P.;Witteman, Jacqueline C. M.;Hartikainen, Anna-Liisa;Beckmann, Jacques S.;Boerwinkle, Eric;Vasan, Ramachandran S.;Boehnke, Michael;Larson, Martin G.;Jarvelin, Marjo-Riitta;Psaty, Bruce M.;Abecasis, Goncalo R.;Chakravarti, Aravinda;Elliott, Paul;van Duijn, Cornelia M.;Newton-Cheh, Christopher;Levy, Daniel;Caulfield, Mark J.;Johnson, Toby
通讯作者：
Johnson, Toby
影响因子：
9.8
作者：
Lenfant, Claude
通讯作者：
Lenfant, Claude
影响因子：
30.8
作者：
Marchini, Jonathan;Howie, Bryan;Donnelly, Peter
通讯作者：
Donnelly, Peter
影响因子：
30.8
作者：
Hattersley, AT;Beards, F;Ellard, S
通讯作者：
Ellard, S
影响因子：
30.8
作者：
Ikram, M. Arfan;Fornage, Myriam;Smith, Albert V.;Seshadri, Sudha;Schmidt, Reinhold;Debette, Stephanie;Vrooman, Henri A.;Sigurdsson, Sigurdur;Ropele, Stefan;Taal, H. Rob;Mook-Kanamori, Dennis O.;Coker, Laura H.;Longstreth, W. T., Jr.;Niessen, Wiro J.;DeStefano, Anita L.;Beiser, Alexa;Zijdenbos, Alex P.;Struchalin, Maksim;Jack, Clifford R., Jr.;Rivadeneira, Fernando;Uitterlinden, Andre G.;Knopman, David S.;Hartikainen, Anna-Liisa;Pennell, Craig E.;Thiering, Elisabeth;Steegers, Eric A. P.;Hakonarson, Hakon;Heinrich, Joachim;Palmer, Lyle J.;Jarvelin, Marjo-Riitta;McCarthy, Mark I.;Grant, Struan F. A.;St Pourcain, Beate;Timpson, Nicholas J.;Smith, George Davey;Sovio, Ulla;Nalls, Mike A.;Au, Rhoda;Hofman, Albert;Gudnason, Haukur;van der Lugt, Aad;Harris, Tamara B.;Meeks, William M.;Vernooij, Meike W.;van Buchem, Mark A.;Catellier, Diane;Jaddoe, Vincent W. V.;Gudnason, Vilmundur;Windham, B. Gwen;Wolf, Philip A.;van Duijn, Cornelia M.;Mosley, Thomas H., Jr.;Schmidt, Helena;Launer, Lenore J.;Breteler, Monique M. B.;DeCarli, Charles;Adair, Linda S.;Ang, Wei;Atalay, Mustafa;vanBeijsterveldt, Toos;Bergen, Nienke;Benke, Kelly;Berry, Diane;Coin, Lachlan;Davis, Oliver S. P.;Elliott, Paul;Flexeder, Claudia;Frayling, Tim;Gaillard, Romy;Groen-Blokhuis, Maria;Goh, Liang-Kee;Haworth, Claire M. A.;Hadley, Dexter;Hedebrand, Johannes;Hinney, Anke;Hirschhorn, Joel N.;Holloway, John W.;Holst, Claus;Hottenga, Jouke Jan;Horikoshi, Momoko;Huikari, Ville;Hypponen, Elina;Kilpelainen, Tuomas O.;Kirin, Mirna;Kowgier, Matthew;Lakka, Hanna-Maaria;Lange, Leslie A.;Lawlor, Debbie A.;Lehtimaki, Terho;Lewin, Alex;Lindgren, Cecilia;Lindi, Virpi;Maggi, Reedik;Marsh, Julie;Middeldorp, Christel;Millwood, Iona;Murray, Jeffrey C.;Nivard, Michel;Nohr, Ellen Aagaard;Ntalla, Ioanna;Oken, Emily;Panoutsopoulou, Kalliope;Pararajasingham, Jennifer;Rodriguez, Alina;Salem, Rany M.;Sebert, Sylvain;Siitonen, Niina;Strachan, David P.;Teo, Yik-Ying;Valcarcel, Beatriz;Willemsen, Gonneke;Zeggini, Eleftheria;Boomsma, Dorret I.;Cooper, Cyrus;Gillman, Matthew;Hocher, Berthold;Lakka, Timo A.;Mohlke, Karen L.;Dedoussis, George V.;Ong, Ken K.;Pearson, Ewan R.;Price, Thomas S.;Power, Chris;Raitakari, Olli T.;Saw, Seang-Mei;Scherag, Andre;Simell, Olli;Sorensen, Thorkild I. A.;Wilson, James F.
通讯作者：
Wilson, James F.