SETD4-expressing cells contribute to pancreatic development and response to cerulein induced pancreatitis injury.
SETD4-expressing cells contribute to pancreatic development and response to cerulein induced pancreatitis injury.
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SETD4表达细胞有助于胰腺发育和对雨蛙蛋白诱导的胰腺炎损伤的反应
DOI：
10.1038/s41598-021-92075-5
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发表时间：
2021-06-15
影响因子：
4.6
通讯作者：
Yang WJ
中科院分区：
文献类型：
--
作者：
Tian JZ;Xing S;Feng JY;Yang SH;Ding YF;Huang XT;Yang JS;Yang WJ
In the adult pancreas, the presence of progenitor or stem cells and their potential involvement in homeostasis and regeneration remains unclear. Here, we identify that SET domain-containing protein 4 (SETD4), a histone lysine methyltransferase, is expressed in a small cell population in the adult mouse pancreas. Genetic lineage tracing shows that during pancreatic development, descendants of SETD4+cells make up over 70% of pancreatic cells and then contribute to each pancreatic lineage during pancreatic homeostasis. SETD4+cells generate newborn acinar cells in response to cerulein-induced pancreatitis in acinar compartments. Ablation of SETD4+cells compromises regeneration of acinar cells, in contrast to controls. Our findings provide a new cellular narrative for pancreatic development, homeostasis and response to injury via a small SETD4+cell population. Potential applications may act to preserve pancreatic function in case of pancreatic disease and/or damage.
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影响因子：
9.8
作者：
Coller HA;Sang L;Roberts JM
通讯作者：
Roberts JM
DOI：
10.1126/science.1180794
发表时间：
2010-01-29
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Li L;Clevers H
通讯作者：
Clevers H
影响因子：
64.8
作者：
JONSSON, J;CARLSSON, L;EDLUND, H
通讯作者：
EDLUND, H
影响因子：
23.9
作者：
Boonsanay, Verawan;Zhang, Ting;Braun, Thomas
通讯作者：
Braun, Thomas
DOI：
10.1073/pnas.0504750102
发表时间：
2005-10-11
影响因子：
11.1
作者：
Akiyama, H;Kim, JE;de Crombrugghe, B
通讯作者：
de Crombrugghe, B