Modulation of 7,12-dimethylbenz[a]anthracene-induced transmammary carcinogenesis by disulfiram and butylated hydroxyanisole in mice.
Modulation of 7,12-dimethylbenz[a]anthracene-induced transmammary carcinogenesis by disulfiram and butylated hydroxyanisole in mice.
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DOI：
10.1111/j.1349-7006.1989.tb01650.x
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发表时间：
1989-12
期刊：
影响因子：
--
通讯作者：
Jannu L
中科院分区：
文献类型：
--
作者：
Rao AR;Hussain SP;Jannu L
The individual as well as combined chemopreventive actions of disulfiram (DSF) and butylated hydroxyanisole (BHA) on 7,12‐dimethylbenz[a]anthracene (DMBA)‐induced transmammary car‐cinogenesis in mice were examined. When nursing mothers receiving normal diet were treated with DMBA (1 mg/mouse) on days 6, 8 and 10 postpartum, the tumor incidence in their 50‐week‐old F1 progeny was 44.1%. When nursing mothers receiving 0.75% BHA diet, 0.5% DSF diet and 0.75% BHA+0.5% DSF diet were similarly treated with DMBA, the tumor incidences in their 50‐week‐old F1 progeny were 14.7% (P<0.05), 12.5% (P<0.05) and 5.8% (P<0.01), respectively. It is concluded that diets containing BHA (0.75%) and DSF (0.5%), singly or in combination, can inhibit trans‐mammary carcinogenesis in Swiss albino mice.
