A Cu9S5 nanoparticle-based CpG delivery system for synergistic photothermal-, photodynamic- and immunotherapy
A Cu9S5 nanoparticle-based CpG delivery system for synergistic photothermal-, photodynamic- and immunotherapy
复制标题
基于 Cu9S5 纳米颗粒的 CpG 递送系统，用于协同光热、光动力和免疫治疗
DOI：
10.1038/s42003-020-1070-6
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发表时间：
2020
影响因子：
5.9
通讯作者：
Shuo Shi
中科院分区：
文献类型：
--
作者：
Lulu Zhou;Lv Chen;Xiaochun Hu;Yonglin Lu;Wenjie Liu;Yanting Sun;Tianming Yao;Chunyan Dong;Shuo Shi
尽管光疗法在癌症治疗中具有巨大的潜力，但光疗法，包括光热疗法（PTT）和光动力疗法（PDT），经常引起肿瘤的转移。免疫治疗由于能够激活免疫系统以消除肿瘤而彻底改变了癌症治疗。然而，将光疗和免疫疗法整合到用于癌症治疗的单一纳米药物中仍然是一项具有挑战性的任务。在这里，我们制造（Cu9S5@mSiO2-PpIX@MnO2@CpG（CSPM@CpG））作为光疗增强免疫疗法的协同治疗模型。细胞内摄取胞嘧啶-磷酸-鸟嘌呤（cytosine-phosphate-guanine，CpG）可促进肿瘤组织中细胞毒性T淋巴细胞（cytotoxic T lymphocytes，CTL）的浸润，进而刺激IFN-γ的产生，显著提高免疫应答水平。协同PTT/PDT/免疫疗法已取得了优异的抗肿瘤效果。CpG的免疫应答可有效抑制肿瘤的转移。因此，我们提出的工作提供了一个策略，联合收割机光疗与免疫治疗，以提高治疗效率，并进一步抑制肿瘤的转移。
Despite its great potential in cancer therapy, phototherapy, including photothermal therapy (PTT) and photodynamic therapy (PDT), often cause metastasis of tumors. Immunotherapy has revolutionized the cancer treatment owing to the capability of activating immune system to eliminate tumors. However, the integration of phototherapy and immunotherapy in a single nanoagent for cancer therapy is still a challenging task. Here, we fabricated (Cu9S5@mSiO2-PpIX@MnO2@CpG (CSPM@CpG)) as a synergistic therapeutic model for phototherapy enhanced immunotherapy. The intracellular uptake of cytosine-phosphate-guanine (CpG) promoted the infiltration of cytotoxic T lymphocytes (CTLs) in tumor tissue, further stimulating the production of interferon gamma (IFN-γ) and remarkably elevating the immune response level. Excellent anti-tumor effects have been achieved by synergistic PTT/PDT/immunotherapy. The metastasis of tumors was effectively inhibited by the immune response of CpG. Thus, our proposed work provides a strategy to combine phototherapy with immunotherapy to enhance the therapeutic efficiency and further inhibit metastasis of tumors.