Pulmonary antioxidant concentrations and oxidative damage in ventilated premature babies
Pulmonary antioxidant concentrations and oxidative damage in ventilated premature babies
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DOI：
10.1136/adc.2002.016717
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发表时间：
2004-09-01
影响因子：
4.4
通讯作者：
Quinn, MW
中科院分区：
文献类型：
--
作者：
Collard, KJ;Godeck, S;Quinn, MW
目的：探讨呼吸机治疗早产儿上皮衬里液中抗坏血酸、尿酸、谷胱甘肽等抗氧化剂与脂质过氧化的关系，并探讨其与临床结局的关系。设计：1999年1月至2001年6月间进行的一项队列研究。地点：NHS新生儿重症监护病房。患者：43例胎龄<32周的呼吸机新生儿。主要观察指标：按支气管肺发育不良(BPD)定义补充氧的时间。方法：采用支气管肺泡灌洗法采集新生儿上皮衬里液。结果：BPD患儿的初始谷胱甘肽浓度显著低于对照组(P=0.043)，丙二醛浓度显著高于对照组(P<0.01)。
Objective: To determine the relation between lipid peroxidation and the antioxidants ascorbate, urate, and glutathione in epithelial lining fluid in ventilated premature babies, and to relate the biochemical findings to clinical outcome.Design: A cohort study conducted between January 1999 and June 2001.Setting: A NHS neonatal intensive care unit.Patients: An opportunity sample of 43 ventilated babies of less than 32 weeks gestation.Main outcome measures: The duration of supplementary oxygen according to the definition of bronchopulmonary dysplasia (BPD; oxygen dependency at 36 weeks gestational age).Methods: Epithelial lining fluid was sampled by bronchoalveolar lavage. Ascorbate, urate, glutathione, and malondialdehyde (a marker of lipid peroxidation) were measured.Results: Babies who developed BPD had significantly lower initial glutathione concentrations (mean (SEM) 1.89 (0.62) v 10.76 (2.79) muM; p=0.043) and higher malondialdehyde concentrations (mean (SEM) 1.3 (0.31) v 0.345 (0.09) muM; p