Assessing vaccine effects in repeated low-dose challenge experiments.
Assessing vaccine effects in repeated low-dose challenge experiments.
复制标题
DOI：
10.1111/j.1541-0420.2009.01189.x
复制
发表时间：
2009-12
期刊：
影响因子：
1.9
通讯作者：
Gilbert PB
中科院分区：
文献类型：
--
作者：
Hudgens MG;Gilbert PB
Evaluation of HIV vaccine candidates in non-human primates (NHPs) is a critical step toward developing a successful vaccine to control the HIV pandemic. Historically, HIV vaccine regimens have been tested in NHPs by administering a single high dose of the challenge virus. More recently, evaluation of candidate HIV vaccines has entailed repeated low-dose challenges which more closely mimic typical exposure in natural transmission settings. In this paper, we consider evaluation of the type and magnitude of vaccine efficacy from such experiments. Based on the principal stratification framework, we also address evaluation of potential immunological surrogate endpoints for infection.
登录
查看更多内容
影响因子：
5.5
作者：
Halloran, ME;Longini, IM;Struchiner, CJ
通讯作者：
Struchiner, CJ
影响因子：
1.9
作者：
Gilbert, Peter B.;Hudgens, Michael G.
通讯作者：
Hudgens, Michael G.
影响因子：
6.4
作者：
Qin, Li;Gilbert, Peter B.;Self, Steven G.
通讯作者：
Self, Steven G.
影响因子：
3.7
作者：
Ellenberger, Dennis;Otten, Ronald A.;Butera, Salvatore
通讯作者：
Butera, Salvatore
影响因子：
1.9
作者：
Frangakis, CE;Rubin, DB
通讯作者：
Rubin, DB