THE DISTRIBUTION OF THALAMIC PROJECTION NEURONS CONTAINING CHOLECYSTOKININ MESSENGER-RNA, USING INSITU HYBRIDIZATION HISTOCHEMISTRY AND RETROGRADE LABELING
THE DISTRIBUTION OF THALAMIC PROJECTION NEURONS CONTAINING CHOLECYSTOKININ MESSENGER-RNA, USING INSITU HYBRIDIZATION HISTOCHEMISTRY AND RETROGRADE LABELING
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DOI：
10.1016/0169-328x(88)90024-1
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发表时间：
1988-11-01
期刊：
影响因子：
--
通讯作者：
YOUNG, WS
中科院分区：
文献类型：
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作者：
BURGUNDER, JM;YOUNG, WS
使用原位杂交组织化学研究了丘脑中胆囊收缩素（CCK）合成神经元的分布。 CCK 的信息编码以不同强度水平存在于前、腹、内侧和外侧核组的几乎所有神经元 (95%) 中，其中腹侧具有最高的颗粒密度。内侧和背外侧膝状体核的许多神经元（90%）也含有高水平的 CCK 转录本。束旁核和室旁核中很少有神经元表达 CCK（分别为 2% 和 10%），而其他层内核和中线核则具有中等水平的 CCK 转录本（75% 的神经元）。腹侧外侧膝状核和网状核完全没有信号。注射荧光染料后。 Fluorogold，进入皮层和纹状体的几个区域，丘脑中几乎所有逆行标记的细胞（束旁核除外）都表达CCK基因。
The distribution of cholecystokinin (CCK) synthesizing neurons in the thalamus was studied using in sitgu hybridization histochemistry. The message coding for CCK is present at different levels of intensity in almost all neurons (95%) of the anterior, ventral, medial and lateral groups of nuclei, with the ventral having the highest grain density. Many neurons (90%) of the medial and dorsal lateral geniculate nuclei also contained high levels of CCK transcripts. Very few neurons were found to express CCK in the parafascicular and paraventricular nuclei (2% and 10%, respectively), whereas the other intralaminar and midline nuclei had intermediate levels of CCK transcripts (75% of the neurons). The ventral lateral geniculate nucleus and the reticular nucleus were completely devoid of signal. After injection of the fluorescent dye. Fluorogold, into several areas of the cortex and corpus striatum, almost all retrogradely labeled cells in the thalamus (except in the parafascicular nucleus) expressed the CCK gene.