Suppression of Vasopressin Secretion by Clonidine:Effect of α-Adrenoceptor Antagonists
Suppression of Vasopressin Secretion by Clonidine:Effect of α-Adrenoceptor Antagonists
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可乐定抑制加压素分泌：α-肾上腺素受体拮抗剂的作用
DOI：
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发表时间：
1979
期刊：
影响因子：
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通讯作者：
L. Keil
中科院分区：
文献类型：
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作者：
I. Reid;P. L. Nolan;J. Wolf;L. Keil
在麻醉犬中进行研究，以确定可乐定的利尿作用是否是由抑制血管加压素分泌引起的。静脉注射可乐定（30 μg/kg）使血浆加压素浓度（RIA测定）从10.9 ± 1.5降至5.0 ± 1.1pg/ml（P > 0.01），并伴有动脉血压一过性升高和心率减慢。静脉注射两种α-肾上腺素能受体拮抗剂哌洛恶烷和酚妥拉明，可完全消除可乐定的升压作用，但不能阻止血浆加压素浓度的抑制。可乐定使酚妥拉明治疗犬的血浆血管加压素浓度从11.9 ± 3.1降至3.3 ± 1.0 pg/ml（P > 0.01），使哌咯烷治疗犬的血浆血管加压素浓度从18.1 ± 4.5降至12.4 ± 3.6 pg/ml（P > 0.05）。这些结果为可乐定的利尿作用是由于抑制血管加压素的分泌提供了直接证据。这种抑制似乎不是升压效应的结果。
Studies were performed in anesthetized dogs to determine if the diuretic effect of clonidine results from inhibition of vasopressin secretion. Intravenous clonidine (30 μg/kg) decreased plasma vasopressin concentration (as measured by RIA) from 10.9 ± 1.5 to 5.0 ± 1.1 pg/ml (P > 0.01) in association with a transient increase in arterial blood pressure and a decrease in heart rate. Intravenous administration of two α-adrenoceptor antagonists, piperoxane and phentolamine, virtually abolished the pressor effect of clonidine but did not prevent the suppression of plasma vasopressin concentration. Clonidine decreased plasma vasopressin concentration from 11.9 ± 3.1 to 3.3 ± 1.0 pg/ml in the phentolamine-treated dogs (P > 0.01) and from 18.1 ± 4.5 to 12.4 ± 3.6 pg/ml in the piperoxane-treated dogs (P > 0.05). These results provide direct evidence that the diuretic effect of clonidine results from inhibiti on of the secretion of vasopressin. This inhibition does not appear to be a consequence of the pressor effe...