Chromosome studies on normal and leukemic human leukocytes.
Chromosome studies on normal and leukemic human leukocytes.
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DOI：
10.1093/jnci/25.1.85
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发表时间：
1960-07
期刊：
影响因子：
--
通讯作者：
P. Nowell;D. Hungerford
中科院分区：
文献类型：
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作者：
P. Nowell;D. Hungerford
本文对4例急性或慢性粒细胞性白血病患者（3例男性，1例女性）外周血中的破髓细胞和3例健康人（1例女性，2例女性）的白细胞进行了研究。细胞在培养物中生长2至4天，然后进行培养。正常细胞和白血病细胞的前中期染色体数目均为46。但2例慢性粒细胞白血病的特征性染色体分析显示有明确的异常，可能涉及Y染色体。没有chroIllo SOIlle异常是可接受的！2例急性白血病（1例患儿，1例女患儿）均为阴性。结果表明，在SOUle白血病中，白细胞sUlall但明确的Chr 0110 sOllal变化是明显的。J. Nat. Cancer Inst.25：85-109，1960。
SUMMARY ChromosOJ:ne studies were Ulade on myelohlasts obtained from the peri pheral blood of 4 patients (3 males, 1 feUlale) with acute or chronic granu locytic leukeUlia and on leukocytes froUl 3 healthy individuals (1 Ulale, 2 feUlales). The cells were grown in cul ture for 2 to 4 days before exaUlination. Both in normal and in leukeIllic cells, the predOJninant Dletaphase chroUlo some nUIllber was 46. However, idio-gram analyses revealed a definite abnor Ulality, probably involving the Y chro mosome, in the 2 cases of chronic granulocytic leukemia. No chroIllo SOIlle abnormality was distinguil!hable in the 2 cases of acute leukeUlia (1 Illale, 1 feUlale) investigated. The results indicate that in SOUle leukeUlic hUUlan leukocytes sUlall but definite ChrOlllO sOIllal changes are demonstrahle.-J. Nat. Cancer Inst. 25: 85-109, 1960.