Considerations for MRI study design and implementation in pediatric and clinical populations.
Considerations for MRI study design and implementation in pediatric and clinical populations.
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DOI：
10.1016/j.dcn.2015.12.005
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发表时间：
2016-04
影响因子：
4.7
通讯作者：
Schlaggar BL
中科院分区：
文献类型：
--
作者：
Greene DJ;Black KJ;Schlaggar BL
人类神经成像，特别是磁共振成像（MRI），正在越来越受欢迎地用于研究发育和疾病中的大脑结构和功能。当将这些方法应用于发育和临床人群时，必须仔细考虑研究设计和实施。在这篇文章中，我们讨论了两个主要的考虑，特别是有关大脑研究的特殊人群。首先，我们讨论了受试者选择和表征的考虑因素，包括与合并症、药物治疗状态和临床评估相关的问题。其次，我们讨论了获取足够的、可用的MRI数据的方法和注意事项。考虑到儿童和患者可能会对扫描仪环境感到焦虑，从而阻止参与，并且他们具有较高的运动伪影风险，导致数据丢失，成功的受试者依从性和数据采集不是微不足道的任务。我们的结论是，作为研究人员，我们必须考虑一些问题时，使用神经影像学工具来研究儿童和患者，我们应该深思熟虑地证明我们的方法和研究设计的选择。
Human neuroimaging, specifically magnetic resonance imaging (MRI), is being used with increasing popularity to study brain structure and function in development and disease. When applying these methods to developmental and clinical populations, careful consideration must be taken with regard to study design and implementation. In this article, we discuss two major considerations particularly pertinent to brain research in special populations. First, we discuss considerations for subject selection and characterization, including issues related to comorbid conditions, medication status, and clinical assessment. Second, we discuss methods and considerations for acquisition of adequate, useable MRI data. Given that children and patients may experience anxiety with the scanner environment, preventing participation, and that they have a higher risk of motion artifact, resulting in data loss, successful subject compliance and data acquisition are not trivial tasks. We conclude that, as researchers, we must consider a number of issues when using neuroimaging tools to study children and patients, and we should thoughtfully justify our choices of methods and study design.