Blood kinetics of ethyl glucuronide and ethyl sulphate in heavy drinkers during alcohol detoxification
Blood kinetics of ethyl glucuronide and ethyl sulphate in heavy drinkers during alcohol detoxification
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DOI：
10.1016/j.forsciint.2009.03.017
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发表时间：
2009-07-01
影响因子：
2.2
通讯作者：
Morland, Jorg
中科院分区：
文献类型：
--
作者：
Hoiseth, Gudrun;Morini, Luca;Morland, Jorg
乙基葡萄糖醛酸酯（EtG）的血液动力学研究迄今已在摄入低至中等剂量乙醇的健康志愿者身上进行。这些数据不一定适用于酒精消耗量高得多的酗酒者。本研究的目的是研究重度饮酒者停止饮酒后血液中EtG和硫酸乙酯（EtS）的药代动力学。16名来自戒酒诊所的患者在入院后直接纳入研究。记录饮酒结束时间、估计每日乙醇摄入量（EDI）和病史。每例患者入院后20-43小时采集3 - 5份血样。平均EDI为172 g（范围60-564）。第一次取样在饮用结束后中位数2.5小时（范围0.5-23.5）采集。两名患者的EtG和EtS水平均低于限定限，第一名患者分别在停止饮酒后19.25和23.5小时采集。在剩下的14名患者中，有一名同时患有肾脏和肝脏疾病的患者，其EtG和EtS的浓度明显高于其他患者。该患者EtG的初始值为17.9 mg/L， EtS的初始值为5.9 mg/L， EtG和EtS的最终消除半衰期分别为11.9 h和12.5 h。在其余13例患者中，初始中位值为：乙醇为0.7 g/L（范围0-3.7），EtG为1.7 mg/L（范围0.1-5.9），EtS为0.9 mg/L（范围0.1-1.9）。EtG的中位半衰期为3.3小时（范围2.6-4.3），EtS的中位半衰期为3.6小时（范围2.7-5.4）。综上所述，重度饮酒者的EtG消除与健康志愿者没有显著差异，而且EtG的消除率似乎相似。在目前的工作中，有一个例外，我们认为这可以解释为患者的肾脏疾病，这将延迟这些结合代谢物的排泄。2009爱思唯尔爱尔兰有限公司版权所有。
Studies of ethyl glucuronide (EtG) blood kinetics have so far been performed on healthy volunteers with ingestion of low to moderate doses of ethanol. These data are not necessarily transferable to heavy drinkers where the consumed doses of ethanol are much higher. The aim of this study was to investigate the pharmacokinetics of EtG and ethyl sulphate (EtS) in blood in heavy drinkers after termination of alcohol ingestion.Sixteen patients from an alcohol withdrawal clinic were included directly after admission. Time of end of drinking, estimated daily intake of ethanol (EDI) and medical history were recorded. Three to five blood samples over 20-43 h were collected from each patient subsequent to admission.The median EDI was 172 g (range 60-564). The first sample was collected median 2.5 h after end of drinking (range 0.5-23.5). Two patients had levels of EtG and EtS below LOQ in all samples, the first collected 19.25 and 23.5 h after cessation of drinking, respectively. Of the remaining 14 patients, one subject, suffering from both renal and hepatic disease, showed concentrations of EtG and EtS substantially higher than the rest of the material. This patient's initial value of EtG was 17.9 mg/L and of EtS 5.9 mg/L, with terminal elimination half lives of 11.9 h for EtG and 12.5 h for EtS. Among the remaining 13 patients, the initial median values were 0.7 g/L (range 0-3.7) for ethanol, 1.7 mg/L (range 0.1-5.9) for EtG and 0.9 mg/L (range 0.1-1.9) for EtS. Elimination occurred with a median half-life of 3.3 h for EtG (range 2.6-4.3) and 3.6 h for EtS (range 2.7-5.4).In conclusion, elimination of EtG in heavy drinkers did not significantly differ from healthy volunteers, and EtS appeared to have similar elimination rate. In the present work, there was one exception to this, and we propose that this could be explained by the patient's renal disease, which would delay excretion of these conjugated metabolites. (C) 2009 Elsevier Ireland Ltd. All rights reserved.