High saturated fatty acid intake induces insulin secretion by elevating gastric inhibitory polypeptide levels in healthy individuals
High saturated fatty acid intake induces insulin secretion by elevating gastric inhibitory polypeptide levels in healthy individuals
复制标题
DOI：
10.1016/j.nutres.2014.07.013
复制
发表时间：
2014-08-01
影响因子：
4.5
通讯作者：
Seino, Yutaka
中科院分区：
文献类型：
--
作者：
Itoh, Kazue;Moriguchi, Ririko;Seino, Yutaka
胰岛素抵抗是代谢综合征系列疾病的核心病因学。有证据表明，高脂肪饮食与胰岛素抵抗有关，这可能是由饮食中的脂肪酸组成调节的。我们假设高饱和脂肪酸摄入会增加胰岛素和胃抑制多肽(GIP)的分泌。为了阐明摄入的脂肪酸组成对血糖水平的影响，我们进行了一项干预性研究，调查了11名健康女性的胰岛素和血浆GIP反应，其中包括一名饮食对照组。对照组每日进餐(F-20；饱和脂肪酸/单不饱和脂肪酸/多不饱和脂肪酸[S/男/多不饱和脂肪酸比例为3：4：3])加20能(E)%脂肪，随后给予2顿等能实验餐，每餐7天。这些膳食含有605%的碳水化合物、15%的蛋白质和30%的脂肪(FB-30；高饱和脂肪酸膳食；S/WP，5：4：1；F-30：低饱和脂肪酸膳食；S/WP，3：4：3)。在F-20的第二天、F-30和FB-30的最后一天，在进餐耐量试验前以及30、60和120分钟后采集血样。F-20和FB-30或F-30的血糖反应没有差别。然而，FB-30之后的胰岛素水平高于F-20之后(P<；.01)。FB-30后的GIP反应高于F-30后(P<；0.05)。此外，FB-30和F-30之间GIP增量的差异与胰岛素增量的差异显著正相关。这些结果表明，高饱和脂肪酸含量通过增加GIP分泌来刺激餐后胰岛素的释放。(C)2014 Elsevier Inc.保留所有权利。
Insulin resistance is central to the etiology of the metabolic syndrome cluster of diseases. Evidence suggests that a high-fat diet is associated with insulin resistance, which may be modulated by dietary fatty acid composition. We hypothesized that high saturated fatty acid intake increases insulin and gastric inhibitory polypeptide (GIP) secretion. To clarify the effect of ingested fatty acid composition on glucose levels, we conducted an intervention study to investigate the insulin and plasma GIP responses in 11 healthy women, including a dietary control. Subjects were provided daily control meals (F-20; saturated fatty acids/monounsaturated fatty acids/polyunsaturated fatty acids [S/M/P] ratio, 3:4:3) with 20 energy (E) % fat, followed by 2 isoenergetic experimental meals for 7 days each. These meals comprised 605% carbohydrate, 15 E% protein, and 30 E% fat (FB-30; high saturated fatty acid meal; S/WP, 5:4:1; F-30: reduced saturated fatty acid meal; S/WP, 3:4:3). On the second day of the F-20 and the last day of F-30 and FB-30, blood samples were taken before and 30, 60, and 120 minutes after a meal tolerance test. The plasma glucose responses did not differbetween F-20 and FB-30 or F-30. However, insulin levels were higher after the FB-30 than after the F-20 (P < .01). The GIP response after the FB-30 was higher than that after the F-30 (P < .05). In addition, the difference in the incremental GIP between FB-30 and F-30 correlated significantly and positively with that of the insulin. These results suggest that a high saturated fatty acid content stimulates postprandial insulin release via increased GIP secretion. (C) 2014 Elsevier Inc. All rights reserved.