Comprehensive analysis of human leukocyte antigen class I alleles and cervical neoplasia in 3 epidemiologic studies
Comprehensive analysis of human leukocyte antigen class I alleles and cervical neoplasia in 3 epidemiologic studies
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DOI：
10.1086/342295
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发表时间：
2002-09-01
影响因子：
6.4
通讯作者：
Carrington, M
中科院分区：
文献类型：
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作者：
Wang, SS;Hildesheim, A;Carrington, M
为了全面探讨人类白细胞抗原（HLA）I类等位基因与宫颈肿瘤之间的关系，对来自美国和哥斯达黎加3项大型宫颈研究的一部分参与者进行了HLA I类等位基因分型。研究受试者为宫颈癌或高度鳞状上皮病变（HSIL; n=365）或低度鳞状上皮病变（LSIL; n=275）或细胞学正常的女性（对照受试者; n=681）。等位基因与疾病的相关性通过逻辑回归分析进行评估。在所有研究中观察到HLA-CW*0202的一致相关性，与对照受试者相比，癌症或HSIL的合并比值比为0.53（95%置信区间[CI]，0.29-0.89），LSIL为0.58（95% CI，0.37-1.04），并进行了研究调整。这一发现支持了这样的假设，即一个等位基因可能足以保护对宫颈肿瘤。鉴于HLA-C与自然杀伤（NK）细胞上的受体之间的关系，提出了NK功能在人乳头瘤病毒感染和宫颈瘤变中的作用。
To comprehensively explore the relationship between human leukocyte antigen (HLA) class I alleles and cervical neoplasia, a subset of participants from 3 large US and Costa Rican cervix studies were typed for HLA class I alleles. Study subjects were women with cervical cancer or high-grade squamous epithelial lesions (HSILs; n=365) or low-grade squamous epithelial lesions (LSILs; n=275) or who were cytologically normal (control subjects; n=681). Allele-disease associations were assessed by logistic regression analysis. Consistent associations across all studies were observed for HLA-CW*0202 with a combined odds ratio of 0.53 (95% confidence interval [CI], 0.29-0.89) for cancer or HSILs and 0.58 (95% CI, 0.37-1.04) for LSILs, compared with control subjects and adjusted for study. This finding supports the hypothesis that a single allele may be sufficient to confer protection against cervical neoplasia. Given the relationship between HLA-C and its receptors on natural killer (NK) cells, a role is proposed for NK function in human papillomavirus infection and cervical neoplasia.